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体外“自发”转化后源自小鼠细胞的肿瘤结构。

The structure of tumours derived from mouse cells after "spontaneous" transformation in vitro.

作者信息

Franks L M, Chesterman F C, Rowlatt C

出版信息

Br J Cancer. 1970 Dec;24(4):843-8. doi: 10.1038/bjc.1970.99.

DOI:10.1038/bjc.1970.99
PMID:5533949
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2008703/
Abstract

The histological structure of 58 primary tumours derived from spontaneously transformed tissue culture cell lines from embryonic (14-16 days), young (3-20 days) and old (28-34 months) C3H and C57 mice is described. Although the cell lines were derived from a number of different organs the tumours were similar in morphology. The pattern was mixed, with "fibrosarcomatous", "myxoid", "epithelioid" and giant cell areas. The tumours resemble some types of haemangiopericytoma.

摘要

本文描述了从胚胎期(14 - 16天)、幼年期(3 - 20天)和老年期(28 - 34个月)的C3H和C57小鼠自发转化的组织培养细胞系中获得的58个原发性肿瘤的组织学结构。尽管这些细胞系来源于多个不同器官,但肿瘤在形态上相似。其模式是混合性的,有“纤维肉瘤样”、“黏液样”、“上皮样”和巨细胞区域。这些肿瘤类似于某些类型的血管外皮细胞瘤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be1/2008703/26b1a54d2e69/brjcancer00469-0261-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be1/2008703/ddc6e8c84b87/brjcancer00469-0262-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be1/2008703/34d2771a4cb2/brjcancer00469-0263-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be1/2008703/26b1a54d2e69/brjcancer00469-0261-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be1/2008703/ddc6e8c84b87/brjcancer00469-0262-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be1/2008703/34d2771a4cb2/brjcancer00469-0263-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2be1/2008703/26b1a54d2e69/brjcancer00469-0261-a.jpg

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本文引用的文献

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The glomus tumor: Investigation of its distribution and behavior, and the identity of its "epithelioid" cell.血管球瘤:对其分布及行为的研究,以及其“上皮样”细胞的特性。
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Induction of tumors in rats by tissue-culture preparations of SE polyoma virus.用SE多瘤病毒的组织培养制剂在大鼠中诱发肿瘤。
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Neoplasms in the C3H strain and in F1 hybrid mice of two crosses following introduction of extracts and filtrates of leukemic tissues.在引入白血病组织提取物和滤液后,C3H品系以及两个杂交组合的F1杂种小鼠中的肿瘤。
J Natl Cancer Inst. 1955 Oct;16(2):495-539.