Levy S, Papadopoulo D, Nocentini S, Markovits P M
C R Acad Hebd Seances Acad Sci D. 1975 Jun 30;280(25):2905-8.
A transformed and malignant cell line was obtained by treatment of secondary hamster embryo cells with 7-methyl benz(a)anthracene (10 mug/ml of medium). Later on these cells acquired the capacity to grow spontaneously in suspension and form "spheroids". The evolution of this cell line showed similarities between the carcinogenic process in vitro and in vivo.
通过用7-甲基苯并(a)蒽（每毫升培养基10微克）处理仓鼠胚胎二代细胞，获得了一种转化的恶性细胞系。后来这些细胞获得了在悬浮液中自发生长并形成“球体”的能力。该细胞系的演变显示出体外和体内致癌过程之间的相似性。
