Kovalev G V, Spasov A A
Farmakol Toksikol. 1975 Jul-Aug;38(4):449-53.
It is shown that following a one-time intravenous administration to rats of ethyron, epinephrine and pituitrin (in doses causing hypertension) the amount of the blood plasma kininogen is more than halved with concurrently increasing caseinolysis. A two-day long introduction of these substances activates prekallicrein and brings down the level of the kallicrein inhibitors, whereas a 10 and 20-day coursewise administration of these compounds intensifies the synthesis of some components in the kallicrein-kinine system.
