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脂肪消化过程中人体肠道内容物中的液晶相。

A liquid crystalline phase in human intestinal contents during fat digestion.

作者信息

Holt P R, Fairchild B M, Weiss J

出版信息

Lipids. 1986 Jul;21(7):444-6. doi: 10.1007/BF02536401.

DOI:10.1007/BF02536401
PMID:3747737
Abstract

A viscous, gel-like phase was found in ultracentrifuged human upper intestinal contents collected during rapid fat lipolysis. This "gel" phase was layered in the ultracentrifuge tube between the micellar and oil phase. The gel contained lipids typical of the micellar and not the oil phase. The concentration of these lipids was higher and the ratio of total bile salts to lipids was lower in the gel than in the micellar phase. The gel, unlike the micellar phase, was birefringent between crossed polarizers. These data demonstrate that lipids in this gel phase can form liquid crystals in the gut during fat digestion.

摘要

在快速脂肪分解过程中收集的超速离心后的人体上段肠道内容物中发现了一种粘性的、凝胶状相。这种“凝胶”相在超速离心管中位于胶束相和油相之间。该凝胶含有典型的胶束相脂质而非油相脂质。这些脂质在凝胶中的浓度高于胶束相,且总胆汁盐与脂质的比率低于胶束相。与胶束相不同,该凝胶在正交偏振器之间具有双折射性。这些数据表明,在脂肪消化过程中,该凝胶相中的脂质可在肠道中形成液晶。

相似文献

1
A liquid crystalline phase in human intestinal contents during fat digestion.脂肪消化过程中人体肠道内容物中的液晶相。
Lipids. 1986 Jul;21(7):444-6. doi: 10.1007/BF02536401.
2
Physical-chemical behavior of dietary and biliary lipids during intestinal digestion and absorption. 2. Phase analysis and aggregation states of luminal lipids during duodenal fat digestion in healthy adult human beings.膳食和胆汁脂质在肠道消化与吸收过程中的物理化学行为。2. 健康成年人十二指肠脂肪消化过程中肠腔脂质的相分析和聚集状态。
Biochemistry. 1990 Feb 27;29(8):2041-56. doi: 10.1021/bi00460a012.
3
Physical-chemical behavior of dietary and biliary lipids during intestinal digestion and absorption. 1. Phase behavior and aggregation states of model lipid systems patterned after aqueous duodenal contents of healthy adult human beings.膳食和胆汁脂质在肠道消化与吸收过程中的物理化学行为。1. 模拟健康成年人类十二指肠内容物的模型脂质体系的相行为和聚集状态。
Biochemistry. 1990 Feb 27;29(8):2028-40. doi: 10.1021/bi00460a011.
4
THE INTRALUMINAL PHASE OF FAT DIGESTION IN MAN: THE LIPID CONTENT OF THE MICELLAR AND OIL PHASES OF INTESTINAL CONTENT OBTAINED DURING FAT DIGESTION AND ABSORPTION.人类脂肪消化的肠腔内阶段:脂肪消化与吸收过程中获得的肠内容物微胶粒相和油相的脂质含量。
J Clin Invest. 1964 Feb;43(2):247-57. doi: 10.1172/JCI104909.
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Isolation and properties of the mixed lipid micelles present in intestinal content during fat digestion in man.人体脂肪消化过程中肠道内容物中混合脂质微团的分离与特性
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引用本文的文献

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Decreased plasma cholesterol concentrations after PUFA-rich diets are not due to reduced cholesterol absorption/synthesis.富含多不饱和脂肪酸(PUFA)的饮食后血浆胆固醇浓度降低并非由于胆固醇吸收/合成减少。
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2
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本文引用的文献

1
THE INTRALUMINAL PHASE OF FAT DIGESTION IN MAN: THE LIPID CONTENT OF THE MICELLAR AND OIL PHASES OF INTESTINAL CONTENT OBTAINED DURING FAT DIGESTION AND ABSORPTION.人类脂肪消化的肠腔内阶段:脂肪消化与吸收过程中获得的肠内容物微胶粒相和油相的脂质含量。
J Clin Invest. 1964 Feb;43(2):247-57. doi: 10.1172/JCI104909.
2
Physico-chemical state of lipids in intestinal content during their digestion and absorption.脂质在消化和吸收过程中肠道内容物中的物理化学状态。
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Phosphorus assay in column chromatography.柱色谱法中的磷测定
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The specificity of pancreatic lipase for the primary hydroxyl groups of glycerides.胰脂肪酶对甘油酯伯羟基的特异性。
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5
Extraction, isolation, and identification of hydrolytic products of triglyceride digestion in man.人体甘油三酯消化水解产物的提取、分离与鉴定。
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6
Effect of sucrose on intestinal very low-density lipoprotein production.蔗糖对肠道极低密度脂蛋白生成的影响。
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7
Aqueous lipid phases of relevance to intestinal fat digestion and absorption.与肠道脂肪消化和吸收相关的水相脂质阶段。
Lipids. 1981 Oct;16(10):749-54. doi: 10.1007/BF02535343.
8
Lipid digestion and absorption.脂质消化与吸收。
Annu Rev Physiol. 1983;45:651-77. doi: 10.1146/annurev.ph.45.030183.003251.
9
Absorption of cholesterol from a micellar solution: intestinal perfusion studies in man.来自胶束溶液的胆固醇吸收:人体肠道灌注研究
J Clin Invest. 1967 May;46(5):874-90. doi: 10.1172/JCI105587.
10
The physicochemical basis of cholesterol gallstone formation in man.人类胆固醇胆结石形成的物理化学基础。
J Clin Invest. 1968 May;47(5):1043-52. doi: 10.1172/JCI105794.