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抗纯化的钙、镁依赖型ATP酶抗体对肌浆网碎片摄取钙离子的抑制作用。

Inhibition of Ca2+ uptake into fragmented sarcoplasmic reticulum by antibodies against purified Ca2+, Mg2+-dependent ATPase.

作者信息

Sumida M, Sasaki S

出版信息

J Biochem. 1975 Oct;78(4):757-62. doi: 10.1093/oxfordjournals.jbchem.a130964.

DOI:10.1093/oxfordjournals.jbchem.a130964
PMID:55412
Abstract

Rabbit antiserum was prepared against a partially purified Ca2+, Mg2+-dependent ATPase [EC 3.6.1.3] of the SR isolated from chicken skeletal muscle. The gamma-globulin fraction of antiserum contained antibodies which combined with the purified ATPase and the SR vesicles. Binding of the antibodies strongly inhibited active transport of Ca2+ ions into the SR, but not passive leakage of Ca2+ ions from the SR. The antibodies scarcely affected the ATPase activity.

摘要

用从鸡骨骼肌中分离出的肌浆网（SR）的部分纯化的Ca2 +、Mg2 +依赖性ATP酶[EC 3.6.1.3]制备兔抗血清。抗血清的γ-球蛋白部分含有与纯化的ATP酶和SR囊泡结合的抗体。抗体的结合强烈抑制Ca2 +离子向SR的主动转运，但不影响Ca2 +离子从SR的被动泄漏。这些抗体几乎不影响ATP酶的活性。

相似文献

1
Inhibition of Ca2+ uptake into fragmented sarcoplasmic reticulum by antibodies against purified Ca2+, Mg2+-dependent ATPase.抗纯化的钙、镁依赖型ATP酶抗体对肌浆网碎片摄取钙离子的抑制作用。
J Biochem. 1975 Oct;78(4):757-62. doi: 10.1093/oxfordjournals.jbchem.a130964.
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引用本文的文献

1
Biomechanical model of the P-type ion pumps of the cell.细胞P型离子泵的生物力学模型。
Naturwissenschaften. 1994 Jan;81(1):21-7. doi: 10.1007/BF01138556.
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Calcium translocation mechanism in sarcoplasmic reticulum vesicles, deduced from location studies of protein-bound spin labels.从蛋白质结合自旋标记的定位研究推导肌浆网囊泡中的钙转运机制。
Proc Natl Acad Sci U S A. 1980 May;77(5):2405-9. doi: 10.1073/pnas.77.5.2405.
3
The sarcoplasmic reticulum Ca2+-ATPase.肌浆网Ca2+ -ATP酶
Mol Cell Biochem. 1982 Feb 5;42(2):83-107. doi: 10.1007/BF00222696.