脱氧胞苷三磷酸脱氨酶：大肠杆菌中该酶缺陷型突变体的特性研究
Deoxycytidine triphosphate deaminase: characterization of an Escherichia coli mutant deficient in the enzyme.
作者信息
O'Donovan G A, Edlin G, Fuchs J A, Neuhard J, Thomassen E
出版信息
J Bacteriol. 1971 Feb;105(2):666-72. doi: 10.1128/jb.105.2.666-672.1971.
Abstract
A mutant of Escherichia coli, previously shown to contain abnormal nucleoside triphosphate pools, was found to be defective in its ability to synthesize thymidine nucleotides. The defect is not in the enzyme thymidylate synthetase but in deoxycytidine triphosphate deaminase, an enzyme that supplies deoxyuridine monophosphate, the substrate for thymidylate synthetase.
摘要
先前已证明含有异常核苷三磷酸库的大肠杆菌突变体，被发现其合成胸苷核苷酸的能力存在缺陷。该缺陷并非存在于胸苷酸合成酶中，而是存在于脱氧胞苷三磷酸脱氨酶中，脱氧胞苷三磷酸脱氨酶是一种提供脱氧尿苷单磷酸的酶，而脱氧尿苷单磷酸是胸苷酸合成酶的底物。
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