青霉素作为一种致痫剂：对孤立突触的作用。
Penicillin as an epileptogenic agent: effect on an isolated synapse.
作者信息
Ayala G F, Spencer W A, Gumnit R J
出版信息
Science. 1971 Mar 5;171(3974):915-7. doi: 10.1126/science.171.3974.915.
PMID:5541657
Abstract
Penicillin enhances the excitatory postsynaptic potential of the squid stellate ganglion. This effect suggests the hypothesis that the epileptic focus created by the topical application of penicillin to the mammalian cerebral cortex is produced by the facilitation of excitatory synaptic coupling within the preexisting positive recurrent feedback system.
摘要
青霉素可增强乌贼星状神经节的兴奋性突触后电位。这一效应提示了这样一种假说：通过将青霉素局部应用于哺乳动物大脑皮层所产生的癫痫病灶，是由预先存在的正反馈系统内兴奋性突触耦合的易化作用所导致的。
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