Proctor E, Matthews G, Archibald J
Thorax. 1971 Jan;26(1):99-102. doi: 10.1136/thx.26.1.99.
Using a storage method based on hypothermic (4° C) perfusion with a water-based asanguinous solution the dog heart has been preserved for up to 72 hours in a viable condition. The ultimate functional test of the viability of such hearts is orthotopic transplantation. Seven of eight dog hearts stored for 72 hours were able to support the recipient circulation in a stable manner after acute orthotopic transplantation. The donor hearts maintained a mean arterial pressure of 70-100 mmHg, left atrial pressure 5-12 cm HO, and maximum dp/dt of the left ventricular pressure was 1,200-2,400 mmHg/second. No myocardial stimulants were used. The results of 72 hours' hypothermic perfusion storage were superior to those of previously reported six hours' non-perfusion storage. A comment is made on the empirical nature of this field.
采用基于4℃低温灌注水性无血溶液的保存方法，犬心脏在存活状态下已被保存长达72小时。此类心脏存活能力的最终功能测试是原位移植。在急性原位移植后，八个保存72小时的犬心脏中有七个能够稳定地支持受体循环。供体心脏维持平均动脉压70 - 100 mmHg，左心房压5 - 12 cm H₂O，左心室压力的最大dp/dt为1200 - 2400 mmHg/秒。未使用心肌兴奋剂。72小时低温灌注保存的结果优于先前报道的6小时非灌注保存的结果。对该领域的经验性质进行了评论。
