Dastur D K, Manghani D K, Raghavendran K V
J Clin Invest. 1971 Jan;50(1):9-20. doi: 10.1172/JCI106487.
The fate and distribution of isotopic manganese administered as a single carrier-free dose of 200 muCi of maleate-(54)Mn to 12 rhesus monkeys was studied at different time periods from the 6th hr to the 278th day. Whole-body activity was measured, and all body organs and tissues and different parts of the central nervous system (CNS) were evaluated for specific activity, exponential analysis, and relative retention. Exponential analysis revealed a pattern of discharge with a fast and a slow component for the whole body and for many of the viscera. All parts of the CNS and, to a lesser degree, the thyroid and muscle showed an almost steady state of activity after the initial uptake. While the whole body and most organs and tissues appeared to discharge their radioactivity with the passage of time, first rapidly and then gradually, the CNS, endocrine glands, and muscle tissues showed persistent levels of specific activity. All components of the brain exhibited increasing relative retention, the lentiform nucleus and the cerebellum showing this more. It is suggested that the selective vulnerability of the brain in manganese miners might result from this inability on the part of the CNS to discharge the (54)Mn with time. This investigation confirms and amplifies our earlier similar study on the rat.
给12只恒河猴单次无载体注射200微居里马来酸 -（54）锰，在从第6小时到第278天的不同时间段研究了同位素锰的命运和分布。测量了全身活性，并评估了所有身体器官和组织以及中枢神经系统（CNS）的不同部位的比活性、指数分析和相对保留率。指数分析显示全身和许多内脏有快速和缓慢成分的排出模式。中枢神经系统的所有部位以及程度较轻的甲状腺和肌肉在最初摄取后显示出几乎稳定的活性状态。虽然全身以及大多数器官和组织似乎随着时间的推移排出其放射性，先是快速然后逐渐排出，但中枢神经系统、内分泌腺和肌肉组织显示出持续的比活性水平。大脑的所有成分都表现出相对保留率增加，豆状核和小脑更为明显。有人认为，锰矿工脑中的选择性易损性可能是由于中枢神经系统无法随时间排出（54）锰所致。本研究证实并扩展了我们早期对大鼠的类似研究。
