氧化直链淀粉和聚丙烯酸对口蹄疫及猪霍乱病毒感染的影响。

Effects of oxyamylose and polyacrylic acid on foot-and-mouth disease and hog cholera virus infections.

作者信息

Leunen J, Desmyter J, De Somer P

出版信息

Appl Microbiol. 1971 Feb;21(2):203-8. doi: 10.1128/am.21.2.203-208.1971.

DOI:10.1128/am.21.2.203-208.1971

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC377150/

Abstract

Two interferon-inducing polycarboxylates were tested for antiviral activity on foot-and-mouth disease (FMD) virus infections in mice, guinea pigs, and swine. Polyacrylic acid, given intraperitoneally, had a protective effect on infection by FMD virus administered in the peritoneal cavity of mice and in the foot pad of guinea pigs. Chlorite-oxidized oxyamylose (COAM) was effective in mice at a dosage of 2 mg/kg. Swine were not protected against naturally transmitted FMD by 120 mg/kg of COAM nor by polyacrylic acid. Swine were not totally unresponsive to COAM since it delayed symptoms of hog cholera. Interferon was not detected in the serum of COAM-treated swine. With FMD virus, an example was found of activity of interferon inducers in experimental hosts and lack of activity in a natural host.

摘要

测试了两种干扰素诱导性多羧酸盐对小鼠、豚鼠和猪口蹄疫（FMD）病毒感染的抗病毒活性。腹腔注射的聚丙烯酸对在小鼠腹腔和豚鼠脚垫中接种的口蹄疫病毒感染具有保护作用。亚氯酸盐氧化直链淀粉（COAM）在剂量为2mg/kg时对小鼠有效。120mg/kg的COAM和聚丙烯酸均不能保护猪免受自然传播的口蹄疫感染。猪对COAM并非完全无反应，因为它能延迟猪霍乱的症状。在接受COAM治疗的猪血清中未检测到干扰素。对于口蹄疫病毒，发现了干扰素诱导剂在实验宿主中有活性而在自然宿主中无活性的一个例子。

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本文引用的文献

1

[Virostasis induced in vivo by non-infectious ribonucleic acids].[非感染性核糖核酸在体内诱导的病毒静止]

C R Hebd Seances Acad Sci. 1963 Jan 21;256:1048-50.

2

[Disorders produced in vivo in the multiplication of viral ribonucleotides].[病毒核糖核苷酸增殖过程中在体内产生的病症]

C R Hebd Seances Acad Sci. 1960 Mar 21;250:2296-8.

3

Antiviral activity of polyacrylic and polymethacrylic acids. II. Mode of action in vivo.聚丙烯酸和聚甲基丙烯酸的抗病毒活性。II. 体内作用方式。

J Virol. 1968 Sep;2(9):886-93. doi: 10.1128/JVI.2.9.886-893.1968.

4

Effect of interferon, polyacrylin acid, and polymethacrylic acid on tail lesions on mice infected with vaccinia virus.干扰素、聚丙烯酸和聚甲基丙烯酸对感染痘苗病毒小鼠尾部损伤的影响。

Appl Microbiol. 1968 Sep;16(9):1314-9. doi: 10.1128/am.16.9.1314-1319.1968.

5

Effect of DEAE-dextran on production of interferon induced by synthetic double-stranded RNA in L cell cultures.二乙氨基乙基葡聚糖对L细胞培养物中合成双链RNA诱导的干扰素产生的影响。

Proc Soc Exp Biol Med. 1968 Jul;128(3):708-10. doi: 10.3181/00379727-128-33105.

6

Inducers of interferon and host resistance. VI. Antiviral efficacy of poly I:C in animal models.干扰素与宿主抵抗力的诱导剂。VI. 聚肌胞苷酸在动物模型中的抗病毒功效。

Proc Soc Exp Biol Med. 1969 Nov;132(2):776-83. doi: 10.3181/00379727-132-34308.

7

Inducers of interferon and host resistance. II. Multistranded synthetic polynucleotide complexes.干扰素与宿主抗性的诱导剂。II. 多链合成多核苷酸复合物。

Proc Natl Acad Sci U S A. 1967 Sep;58(3):1004-10. doi: 10.1073/pnas.58.3.1004.

8

Evaluation of the fluorescent antibody-cell culture test for hog cholera diagnosis.

Am J Vet Res. 1967 Nov;28(127):1653-9.

9

Interferons of foot-and-mouth disease virus: a new assay for interferon.口蹄疫病毒干扰素：一种新的干扰素检测方法。

Arch Gesamte Virusforsch. 1970;30(1):75-81. doi: 10.1007/BF01262585.

10

Antiviral activity of chlorite-oxidized oxyamylose, a polyacetal carboxylic acid.一种聚缩醛羧酸——亚氯酸盐氧化淀粉的抗病毒活性。

J Virol. 1970 Mar;5(3):321-8. doi: 10.1128/JVI.5.3.321-328.1970.

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