De Clercq E, De Somer P
Appl Microbiol. 1968 Sep;16(9):1314-9. doi: 10.1128/am.16.9.1314-1319.1968.
Intravenous inoculation of mice with vaccinia virus produced characteristic lesions of the tail surface which were suppressed by intraperitoneal administration of interferon and polyacrylic acid (PAA). Polymethacrylic acid (PMAA) stimulated the formation of vaccinia virus lesions. For full activity, both interferon and PAA must be given prior to infection. PAA was still significantly effective at small dose levels (3 mg/kg) and achieved protection for at least 4 weeks. Protection increased with increasing molecular weight of the polymer. The mode of action of PAA is discussed.
给小鼠静脉接种痘苗病毒会在尾巴表面产生特征性病变，而腹腔注射干扰素和聚丙烯酸（PAA）可抑制这些病变。聚甲基丙烯酸（PMAA）会刺激痘苗病毒病变的形成。为达到完全活性，干扰素和PAA都必须在感染前给予。PAA在小剂量水平（3毫克/千克）时仍具有显著效果，并且能提供至少4周的保护。随着聚合物分子量的增加，保护作用增强。文中讨论了PAA的作用方式。
