干扰素、聚丙烯酸和聚甲基丙烯酸对感染痘苗病毒小鼠尾部损伤的影响。
Effect of interferon, polyacrylin acid, and polymethacrylic acid on tail lesions on mice infected with vaccinia virus.
作者信息
De Clercq E, De Somer P
出版信息
Appl Microbiol. 1968 Sep;16(9):1314-9. doi: 10.1128/am.16.9.1314-1319.1968.
Abstract
Intravenous inoculation of mice with vaccinia virus produced characteristic lesions of the tail surface which were suppressed by intraperitoneal administration of interferon and polyacrylic acid (PAA). Polymethacrylic acid (PMAA) stimulated the formation of vaccinia virus lesions. For full activity, both interferon and PAA must be given prior to infection. PAA was still significantly effective at small dose levels (3 mg/kg) and achieved protection for at least 4 weeks. Protection increased with increasing molecular weight of the polymer. The mode of action of PAA is discussed.
摘要
给小鼠静脉接种痘苗病毒会在尾巴表面产生特征性病变，而腹腔注射干扰素和聚丙烯酸（PAA）可抑制这些病变。聚甲基丙烯酸（PMAA）会刺激痘苗病毒病变的形成。为达到完全活性，干扰素和PAA都必须在感染前给予。PAA在小剂量水平（3毫克/千克）时仍具有显著效果，并且能提供至少4周的保护。随着聚合物分子量的增加，保护作用增强。文中讨论了PAA的作用方式。
相似文献
1
Effect of interferon, polyacrylin acid, and polymethacrylic acid on tail lesions on mice infected with vaccinia virus.干扰素、聚丙烯酸和聚甲基丙烯酸对感染痘苗病毒小鼠尾部损伤的影响。
Appl Microbiol. 1968 Sep;16(9):1314-9. doi: 10.1128/am.16.9.1314-1319.1968.
2
Antiviral activity of polyacrylic and polymethacrylic acids. II. Mode of action in vivo.聚丙烯酸和聚甲基丙烯酸的抗病毒活性。II. 体内作用方式。
J Virol. 1968 Sep;2(9):886-93. doi: 10.1128/JVI.2.9.886-893.1968.
3
Prolonged antiviral protection by interferon inducers.干扰素诱导剂的持久抗病毒保护作用。
Proc Soc Exp Biol Med. 1969 Nov;132(2):699-703. doi: 10.3181/00379727-132-34291.
4
Antiviral activity of chlorite-oxidized oxyamylose, a polyacetal carboxylic acid.一种聚缩醛羧酸——亚氯酸盐氧化淀粉的抗病毒活性。
J Virol. 1970 Mar;5(3):321-8. doi: 10.1128/JVI.5.3.321-328.1970.
5
Antiviral activity of polyacrylic and polymethacrylic acids. I. Mode of action in vitro.聚丙烯酸和聚甲基丙烯酸的抗病毒活性。I. 体外作用模式。
J Virol. 1968 Sep;2(9):878-85. doi: 10.1128/JVI.2.9.878-885.1968.
6
Polyacetal carboxylic acids: a new group of antiviral polyanions.聚缩醛羧酸：一类新型抗病毒聚阴离子。
J Virol. 1970 Mar;5(3):313-20. doi: 10.1128/JVI.5.3.313-320.1970.
7
Protective effect of interferon and polyacrylic acid in newborn mice infected with a lethal dose of vesicular stomatitis virus.
Life Sci. 1968 Sep 1;7(17):925-33. doi: 10.1016/0024-3205(68)90098-2.
8
Antiviral activity of carbopol, a cross-linked polycarboxylate.交联聚羧酸盐卡波姆的抗病毒活性。
Arch Virol. 1976;52(1-2):151-8. doi: 10.1007/BF01317874.
9
Effects of oxyamylose and polyacrylic acid on foot-and-mouth disease and hog cholera virus infections.氧化直链淀粉和聚丙烯酸对口蹄疫及猪霍乱病毒感染的影响。
Appl Microbiol. 1971 Feb;21(2):203-8. doi: 10.1128/am.21.2.203-208.1971.
10
Protection of rabbits against local vaccinia virus infection by Brucella abortus and polyacrylic acid in the absence of systemic interferon production.在不产生全身性干扰素的情况下，用流产布鲁氏菌和聚丙烯酸保护兔免受局部痘苗病毒感染。
Infect Immun. 1973 Oct;8(4):669-73. doi: 10.1128/iai.8.4.669-673.1973.
引用本文的文献
1
Sixty Years at the Rega Institute.鲁汶大学雷加研究所的六十年
Viruses. 2025 Feb 5;17(2):222. doi: 10.3390/v17020222.
2
Selected Milestones in Antiviral Drug Development.抗病毒药物研发的重要里程碑
Viruses. 2024 Jan 23;16(2):169. doi: 10.3390/v16020169.
3
Specifics of Pharmacokinetics and Biodistribution of 5-Fluorouracil Polymeric Complex.5-氟尿嘧啶高分子复合物的药代动力学和生物分布特点。
Molecules. 2023 Dec 15;28(24):8096. doi: 10.3390/molecules28248096.
4
Effective Respiratory CD8 T-Cell Immunity to Influenza Virus Induced by Intranasal Carbomer-Lecithin-Adjuvanted Non-replicating Vaccines.鼻内给予卡波姆-卵磷脂佐剂的非复制型疫苗诱导的针对流感病毒的有效呼吸道CD8 T细胞免疫
PLoS Pathog. 2016 Dec 20;12(12):e1006064. doi: 10.1371/journal.ppat.1006064. eCollection 2016 Dec.
5
Historical perspectives in the development of antiviral agents against poxviruses.抗痘病毒药物的发展历史。
Viruses. 2010 Jun;2(6):1322-1339. doi: 10.3390/v2061322. Epub 2010 Jun 14.
6
Interferon and its inducers--a never-ending story: "old" and "new" data in a new perspective.干扰素及其诱导剂——一个永无止境的故事：新视角下的“旧”数据与“新”数据
J Infect Dis. 2006 Sep 15;194 Suppl 1(Suppl 1):S19-26. doi: 10.1086/505351.
7
Smallpox antiviral drug development: satisfying the animal efficacy rule.天花抗病毒药物研发：满足动物有效性规则。
Expert Rev Anti Infect Ther. 2006 Apr;4(2):277-89. doi: 10.1586/14787210.4.2.277.
8
Biological activity of an intravenous preparation of human vaccinia immune globulin in mouse models of vaccinia virus infection.人痘苗免疫球蛋白静脉制剂在痘苗病毒感染小鼠模型中的生物活性
Antimicrob Agents Chemother. 2005 Jul;49(7):2634-41. doi: 10.1128/AAC.49.7.2634-2641.2005.
9
Orthopoxvirus targets for the development of antiviral therapies.用于开发抗病毒疗法的正痘病毒靶点。
Curr Drug Targets Infect Disord. 2005 Mar;5(1):17-28. doi: 10.2174/1568005053174627.
10
Cutaneous infections of mice with vaccinia or cowpox viruses and efficacy of cidofovir.用痘苗病毒或牛痘病毒对小鼠进行皮肤感染及西多福韦的疗效
Antiviral Res. 2004 Jul;63(1):33-40. doi: 10.1016/j.antiviral.2004.02.003.
本文引用的文献
1
Interferon-like virus-inhibitor induced in human leukocytes by phytohemagglutinin.植物血凝素在人白细胞中诱导产生的类干扰素病毒抑制剂。
Science. 1965 Jul 16;149(3681):310-1.
2
Response of mice to ectromelia and vaccinia viruses.小鼠对脱脚病病毒和痘苗病毒的反应。
Bacteriol Rev. 1959 Jun;23(2):61-95. doi: 10.1128/br.23.2.61-95.1959.
3
Induction of circulating interferon by synthetic anionic polymers of known composition.已知成分的合成阴离子聚合物诱导循环干扰素的产生。
Nature. 1967 Apr 22;214(5086):416-7. doi: 10.1038/214416a0.
4
Evaluation of antiviral compounds by suppression of tail lesions in vaccinia-infected mice.通过抑制痘苗病毒感染小鼠的尾部损伤来评估抗病毒化合物。
Antimicrob Agents Chemother (Bethesda). 1966;6:536-9.
5
Antiviral activity of polyacrylic and polymethacrylic acids. II. Mode of action in vivo.聚丙烯酸和聚甲基丙烯酸的抗病毒活性。II. 体内作用方式。
J Virol. 1968 Sep;2(9):886-93. doi: 10.1128/JVI.2.9.886-893.1968.
6
Antiviral activity of polyacrylic and polymethacrylic acids. I. Mode of action in vitro.聚丙烯酸和聚甲基丙烯酸的抗病毒活性。I. 体外作用模式。
J Virol. 1968 Sep;2(9):878-85. doi: 10.1128/JVI.2.9.878-885.1968.
Zotero 插件