聚丙烯酸和聚甲基丙烯酸的抗病毒活性。II. 体内作用方式。
Antiviral activity of polyacrylic and polymethacrylic acids. II. Mode of action in vivo.
作者信息
De Somer P, De Clercq E, Billiau A, Schonne E, Claesen M
出版信息
J Virol. 1968 Sep;2(9):886-93. doi: 10.1128/JVI.2.9.886-893.1968.
Abstract
A marked virus-inhibiting potency is obtained in the serum after intraperitoneal injection of polyacrylic acid (PAA) and polymethacrylic acid (PMAA) in mice. Much higher antiviral levels were reached than for other related polymers including dextran sulfate, heparin, polyvinyl sulfate, pyran copolymer, polystyrene sulfonate, and macrodex. The broad antiviral action of PAA and PMAA was attributed both to a direct interference with the virus-cell interaction and the viral ribonucleic acid metabolism and to the formation of an interferon-like factor. Both polyanions differed in interferon-inducing ability: highest serum interferon titer was obtained 18 hr after the intraperitoneal injection of PAA. The mechanism of interferon production by PAA and PMAA is discussed. As described previously for Sindbis virus and endotoxin, the animals also became hyporeactive after injection of PAA.
摘要
给小鼠腹腔注射聚丙烯酸（PAA）和聚甲基丙烯酸（PMAA）后，血清中可获得显著的病毒抑制效力。其抗病毒水平远高于其他相关聚合物，包括硫酸葡聚糖、肝素、聚乙烯硫酸盐、吡喃共聚物、聚苯乙烯磺酸盐和中分子右旋糖酐。PAA和PMAA广泛的抗病毒作用归因于对病毒-细胞相互作用和病毒核糖核酸代谢的直接干扰以及一种干扰素样因子的形成。这两种聚阴离子在诱导干扰素的能力上有所不同：腹腔注射PAA后18小时血清干扰素滴度最高。文中讨论了PAA和PMAA产生干扰素的机制。如先前针对辛德毕斯病毒和内毒素所描述的那样，动物在注射PAA后也会变得反应性降低。
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