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1
Idiotypes on major histocompatibility complex-restricted virus-immune cytotoxic T lymphocytes.主要组织相容性复合体限制的病毒免疫细胞毒性T淋巴细胞上的独特型
J Exp Med. 1981 Jun 1;153(6):1562-73. doi: 10.1084/jem.153.6.1562.
2
Antigen receptors on major histocompatibility complex-restricted T lymphocytes. I. Preparation and characterization of syngeneic antisera against trinitrophenyl-activated T cell blasts and demonstration of their specificity for idiotypes on cytotoxic T lymphocytes.主要组织相容性复合体限制性T淋巴细胞上的抗原受体。I. 抗三硝基苯基激活的T细胞母细胞的同基因抗血清的制备与特性鉴定，以及其对细胞毒性T淋巴细胞独特型特异性的证明。
J Exp Med. 1980 May 1;151(5):1166-87. doi: 10.1084/jem.151.5.1166.
3
Specificity of cytotoxic T cells from athymic mice.无胸腺小鼠细胞毒性T细胞的特异性
J Exp Med. 1980 Sep 1;152(3):688-702. doi: 10.1084/jem.152.3.688.
4
Frequency analysis of cytotoxic T lymphocyte precursors in chimeric mice. Evidence for intrathymic maturation of clonally distinct self-major histocompatibility complex- and allo-major histocompatiblilty complex-restricted virus-specific T cells.嵌合小鼠中细胞毒性T淋巴细胞前体的频率分析。克隆性不同的自身主要组织相容性复合体和同种异体主要组织相容性复合体限制性病毒特异性T细胞胸腺内成熟的证据。
J Exp Med. 1981 Jun 1;153(6):1517-32. doi: 10.1084/jem.153.6.1517.
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Simultaneous expression of H-2-restricted and alloreactive recognition by a cloned line of influenza virus-specific cytotoxic T lymphocytes.流感病毒特异性细胞毒性T淋巴细胞克隆系同时表达H-2限制性识别和同种异体反应性识别。
J Exp Med. 1981 May 1;153(5):1371-6. doi: 10.1084/jem.153.5.1371.
6
Induction of syngeneic cytotoxic T lymphocytes against a B cell tumor. III. MHC class I-restricted CTL recognizes the processed form(s) of idiotype.针对B细胞肿瘤的同基因细胞毒性T淋巴细胞的诱导。III. 主要组织相容性复合体I类限制性细胞毒性T淋巴细胞识别独特型的加工形式。
Cell Immunol. 1992 Oct 15;144(2):455-64. doi: 10.1016/0008-8749(92)90259-r.
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Lysis of hybridoma cells bearing anti-clonotypic surface immunoglobulin by clonotype-expressing alloreactive cytotoxic T cells.表达克隆型的同种异体反应性细胞毒性T细胞对携带抗克隆型表面免疫球蛋白的杂交瘤细胞的裂解作用。
Eur J Immunol. 1985 Oct;15(10):1029-33. doi: 10.1002/eji.1830151013.
8
Thymus dictates major histocompatibility complex (MHC) specificity and immune response gene phenotype of class II MHC-restricted T cells but not of class I MHC-restricted T cells.胸腺决定主要组织相容性复合体（MHC）的特异性以及II类MHC限制性T细胞的免疫反应基因表型，但不决定I类MHC限制性T细胞的免疫反应基因表型。
J Exp Med. 1984 Dec 1;160(6):1752-66. doi: 10.1084/jem.160.6.1752.
9
Modification of tumor cells by a low dose of Newcastle disease virus. Augmentation of the tumor-specific T cell response in the absence of an anti-viral response.低剂量新城疫病毒对肿瘤细胞的修饰。在无抗病毒反应的情况下增强肿瘤特异性T细胞反应。
Eur J Immunol. 1988 Aug;18(8):1159-66. doi: 10.1002/eji.1830180803.
10
Differences in expression of MHC products between several H-2-restricted CTL clones.几个H-2限制性CTL克隆之间MHC产物表达的差异。
J Immunol. 1982 May;128(5):2026-31.

引用本文的文献

1
Identification of idiotypic receptors on reovirus-specific cytolytic T cells.呼肠孤病毒特异性溶细胞性T细胞上独特型受体的鉴定
Proc Natl Acad Sci U S A. 1982 Dec;79(23):7479-83. doi: 10.1073/pnas.79.23.7479.
2
Analysis of the T suppressor cell circuit which regulates contact sensitivity in mice infected with the virus of Newcastle disease.对感染新城疫病毒的小鼠中调节接触敏感性的T抑制细胞回路的分析。
Immunology. 1984 Feb;51(2):305-11.
3
A clone-specific monoclonal antibody that inhibits cytolysis of a cytolytic T cell clone.一种抑制细胞毒性T细胞克隆细胞溶解作用的克隆特异性单克隆抗体。
J Exp Med. 1983 Mar 1;157(3):921-35. doi: 10.1084/jem.157.3.921.
4
Definition of T cell idiotypes using anti-idiotypic antisera produced by immunization with T cell clones.利用用T细胞克隆免疫产生的抗独特型抗血清来定义T细胞独特型。
J Exp Med. 1982 Apr 1;155(4):1100-7. doi: 10.1084/jem.155.4.1100.

本文引用的文献

1
Blocking effect of lyt-2 antibodies on T cell functions.Lyt-2抗体对T细胞功能的阻断作用。
J Exp Med. 1980 Sep 1;152(3):674-87. doi: 10.1084/jem.152.3.674.
2
Specificity of cytotoxic T cells from athymic mice.无胸腺小鼠细胞毒性T细胞的特异性
J Exp Med. 1980 Sep 1;152(3):688-702. doi: 10.1084/jem.152.3.688.
3
Antigen receptors on major histocompatibility complex-restricted T lymphocytes. I. Preparation and characterization of syngeneic antisera against trinitrophenyl-activated T cell blasts and demonstration of their specificity for idiotypes on cytotoxic T lymphocytes.主要组织相容性复合体限制性T淋巴细胞上的抗原受体。I. 抗三硝基苯基激活的T细胞母细胞的同基因抗血清的制备与特性鉴定，以及其对细胞毒性T淋巴细胞独特型特异性的证明。
J Exp Med. 1980 May 1;151(5):1166-87. doi: 10.1084/jem.151.5.1166.
4
Immunological surveillance against altered self components by sensitised T lymphocytes in lymphocytic choriomeningitis.淋巴细胞性脉络丛脑膜炎中致敏T淋巴细胞对自身成分改变的免疫监视。
Nature. 1974 Oct 11;251(5475):547-8. doi: 10.1038/251547a0.
5
Proteolytic cleavage of the viral glycoproteins and its significance for the virulence of Newcastle disease virus.病毒糖蛋白的蛋白水解切割及其对新城疫病毒毒力的意义。
Virology. 1976 Jul 15;72(2):494-508. doi: 10.1016/0042-6822(76)90178-1.
6
Production and characterization of cytotoxic Thy-1 antibody-secreting hybrid cell lines. Detection of T cell subsets.细胞毒性Thy-1抗体分泌杂交细胞系的产生与特性分析。T细胞亚群的检测。
Eur J Immunol. 1979 Nov;9(11):875-86. doi: 10.1002/eji.1830091109.
7
Cross-reactivity patterns of murine cytotoxic T lymphocytes.小鼠细胞毒性T淋巴细胞的交叉反应模式。
Cell Immunol. 1979 Mar 1;43(1):70-81. doi: 10.1016/0008-8749(79)90151-5.
8
On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?关于胸腺在T细胞“组织相容性-2自身识别”分化中的作用：双重识别的证据？
J Exp Med. 1978 Mar 1;147(3):882-96. doi: 10.1084/jem.147.3.882.
9
Immunologic recognition of influenza virus-infected cells. I. Generation of a virus-strain specific and a cross-reactive subpopulation of cytotoxic T cells in the response to type A influenza viruses of different subtypes.流感病毒感染细胞的免疫识别。I. 针对不同亚型甲型流感病毒的应答中，细胞毒性T细胞的病毒株特异性和交叉反应性亚群的产生。
Cell Immunol. 1977 Oct;33(2):423-36. doi: 10.1016/0008-8749(77)90170-8.
10
In a radiation chimaera, host H-2 antigens determine immune responsiveness of donor cytotoxic cells.在辐射嵌合体中，宿主H-2抗原决定供体细胞毒性细胞的免疫反应性。
Nature. 1977 Sep 29;269(5627):417-8. doi: 10.1038/269417a0.

主要组织相容性复合体限制的病毒免疫细胞毒性T淋巴细胞上的独特型

Idiotypes on major histocompatibility complex-restricted virus-immune cytotoxic T lymphocytes.

作者信息

Kees U R

出版信息

J Exp Med. 1981 Jun 1;153(6):1562-73. doi: 10.1084/jem.153.6.1562.

DOI:10.1084/jem.153.6.1562
PMID:6973000
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2186191/
Abstract

Specificity-associated determinants could be demonstrated on major histocompatibility complex (MHC)-restricted virus-immune cytotoxic T lymphocytes (CTL) using antisera raised in syngeneic mice. This result indicates that the number of clonotypes sufficiently small to allow the detection of such idiotypic determinants. The functional properties of three anti-idiotypic antisera were tested in blocking studies and by idiotypic antisera plus complement. Whereas the former test did not reveal any results obtained from binding studies, i.e., all three anti-idiotypic antisera specifically reacted with CTL of the type used for immunization and had no effect on syngeneic influenza-immune CTL, syngeneic alloreactive CTL, or NDV-immune CTL of an H-2-disparate strain. These results are discussed in terms of current models for MHC-restricted CTL responses.

摘要

利用在同基因小鼠中产生的抗血清，可在主要组织相容性复合体（MHC）限制的病毒免疫细胞毒性T淋巴细胞（CTL）上证明与特异性相关的决定簇。这一结果表明，克隆型的数量足够少，足以检测到此类独特型决定簇。在阻断研究以及使用独特型抗血清加补体的实验中，对三种抗独特型抗血清的功能特性进行了测试。虽然前一项测试未从结合研究中得出任何结果，即所有三种抗独特型抗血清都与用于免疫的那种类型的CTL发生特异性反应，而对同基因流感免疫CTL、同基因同种异体反应性CTL或H-2不同品系的新城疫病毒（NDV）免疫CTL均无影响。根据当前关于MHC限制的CTL反应的模型对这些结果进行了讨论。