主要组织相容性复合体限制的病毒免疫细胞毒性T淋巴细胞上的独特型
Idiotypes on major histocompatibility complex-restricted virus-immune cytotoxic T lymphocytes.
作者信息
Kees U R
出版信息
J Exp Med. 1981 Jun 1;153(6):1562-73. doi: 10.1084/jem.153.6.1562.
Abstract
Specificity-associated determinants could be demonstrated on major histocompatibility complex (MHC)-restricted virus-immune cytotoxic T lymphocytes (CTL) using antisera raised in syngeneic mice. This result indicates that the number of clonotypes sufficiently small to allow the detection of such idiotypic determinants. The functional properties of three anti-idiotypic antisera were tested in blocking studies and by idiotypic antisera plus complement. Whereas the former test did not reveal any results obtained from binding studies, i.e., all three anti-idiotypic antisera specifically reacted with CTL of the type used for immunization and had no effect on syngeneic influenza-immune CTL, syngeneic alloreactive CTL, or NDV-immune CTL of an H-2-disparate strain. These results are discussed in terms of current models for MHC-restricted CTL responses.
摘要
利用在同基因小鼠中产生的抗血清，可在主要组织相容性复合体（MHC）限制的病毒免疫细胞毒性T淋巴细胞（CTL）上证明与特异性相关的决定簇。这一结果表明，克隆型的数量足够少，足以检测到此类独特型决定簇。在阻断研究以及使用独特型抗血清加补体的实验中，对三种抗独特型抗血清的功能特性进行了测试。虽然前一项测试未从结合研究中得出任何结果，即所有三种抗独特型抗血清都与用于免疫的那种类型的CTL发生特异性反应，而对同基因流感免疫CTL、同基因同种异体反应性CTL或H-2不同品系的新城疫病毒（NDV）免疫CTL均无影响。根据当前关于MHC限制的CTL反应的模型对这些结果进行了讨论。
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