Circolo A, Bianchi R, Nardelli B, Romani L, Andrielli M
Boll Soc Ital Biol Sper. 1979 Oct 15;55(19):1974-80.
Graded doses of LSTPA or L1210 leukemia cells were injected ip or iv into fully compatible hosts or mice incompatible for Multiple Minor Histocompatibility Loci (MMHL). Three days later the animals were treated with single doses of BCNU, NM, DTIC and VCR. The results showed that NM and VCR could synergize with the weak anti-tumor immune responses of MMHL-histocompatible mice only upon ip injection of the tumor. If the same tumor has been injected iv, only BCNU could synergize with the host's antitumor response. On DTIC treatment, no synergistic effects were detectable for either route of tumor's challenge.
将分级剂量的LSTPA或L1210白血病细胞经腹腔内或静脉内注射到完全相容的宿主或对多个次要组织相容性位点（MMHL）不相容的小鼠体内。三天后，用单剂量的卡莫司汀（BCNU）、丝裂霉素（NM）、达卡巴嗪（DTIC）和长春新碱（VCR）对动物进行治疗。结果表明，只有在腹腔内注射肿瘤时，NM和VCR才能与MMHL组织相容性小鼠微弱的抗肿瘤免疫反应产生协同作用。如果通过静脉内注射相同的肿瘤，则只有BCNU能与宿主的抗肿瘤反应产生协同作用。在用DTIC治疗时，无论肿瘤的攻击途径如何，均未检测到协同作用。
