Christensen H D, Freudenthal R I, Gidley J T, Rosenfeld R, Boegli G, Testino L, Brine D R, Pitt C G, Wall M E
Science. 1971 Apr 9;172(3979):165-7. doi: 10.1126/science.172.3979.165.
The 11-hydroxy metabolites of Delta(8).- and Delta(9)-tetrahydrocannabinol are more active than the parent compounds when administered to mice by either the intravenous or intracerebral route. Both Delta(8)- and Delta(9)-tetrahydrocannabinol are rapidly and extensively metabolized by the liver and not by the brain. The hypothesis that the 11-hydroxy metabolites may be the active form of tetrahydrocannabinol is discussed
当通过静脉内或脑内途径给小鼠给药时，δ⁸-和δ⁹-四氢大麻酚的11-羟基代谢物比母体化合物更具活性。δ⁸-和δ⁹-四氢大麻酚均在肝脏中快速且广泛地代谢，而非在大脑中。文中讨论了11-羟基代谢物可能是四氢大麻酚活性形式的这一假说
