Biagi P, Bocchini S, Vernarecci G
Quad Sclavo Diagn. 1979 Sep;15(3):1007-16.
The AA. studied sulfobromophthalein kinetics in normal subjects and patients with alcoholic cirrhosis by compartmental analysis and by mathematical resolution of disappearance plasmatic curve of BSF. The comparison between the two methods gave some interesting clues for understanding BSF metabolism in alcoholic cirrhosis. From obtained data it seems that BSF clearance in these patients, besides on hepatic uptake, like normal subjects, largerly depends on intact secretory function of the liver.
作者通过房室分析以及对磺溴酞钠血浆消失曲线进行数学解析,研究了正常受试者和酒精性肝硬化患者的磺溴酞钠动力学。两种方法的比较为理解酒精性肝硬化中磺溴酞钠的代谢提供了一些有趣的线索。从所得数据来看,这些患者中磺溴酞钠的清除,除了像正常受试者一样依赖肝脏摄取外,很大程度上还取决于肝脏完整的分泌功能。