Snow D H, Bogan J A, Douglas T A, Thompson H
Vet Rec. 1979 Jul 14;105(2):26-30. doi: 10.1136/vr.105.2.26.
The oral administration of phenylbutazone at a dose rate of approximately 10 mg per kg per day for seven to 14 days resulted in the development of signs of toxicity in seven of eight ponies treated. Clinical signs included anorexia, depression and abdominal oedema. Blood biochemical determinations showed a decrease in total plasma protein and calcium concentrations with an increase in urea concentration. These changes were considered indicative of water retention. Three of the ponies died during treatment following the development of shock. Shock was considered to arise from the submucosal oedema of the large intestine observed on necropsy. Oral ulceration was also found in these animals. In two ponies intravenous administration of phenylbutazone (4.0 mg per kg) for seven days was studied. In one of these ponies a marked decrease in total plasma protein concentration occurred.
以每天每千克约10毫克的剂量口服保泰松，持续7至14天，在接受治疗的8匹小马中有7匹出现了中毒迹象。临床症状包括厌食、抑郁和腹部水肿。血液生化测定显示血浆总蛋白和钙浓度降低，尿素浓度升高。这些变化被认为表明存在水潴留。3匹小马在治疗期间因休克死亡。尸检时发现休克是由大肠黏膜下水肿引起的。这些动物还出现了口腔溃疡。对2匹小马进行了静脉注射保泰松（每千克4.0毫克），持续7天的研究。其中一匹小马的血浆总蛋白浓度显著降低。
