Carrick J B, Papich M G, Middleton D M, Naylor J M, Townsend H G
Department of Veterinary Internal Medicine, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon.
Can J Vet Res. 1989 Apr;53(2):195-201.
The effects of daily intravenous administration of flunixin meglumine at dosages of 0.55, 1.1, 2.2 and 6.6 mg/kg for five days were examined in neonatal foals. Six two day old foals were used to evaluate the effect of each dosage. Foals were examined every day and blood samples collected on days 1, 3 and 6. All foals were euthanized after six days, necropsied and examined for lesions. The major clinical abnormality was diarrhea, but the incidence was not related to the dosage of flunixin meglumine administered. The foals receiving 6.6 mg/kg of flunixin meglumine had significantly more gastrointestinal ulceration and greater cecal pathology and cecal petechiation scores than those foals treated with saline. The foals in the 6.6 mg/kg treatment group had a greater loss of total protein during the study, but the difference was not significant. There were no statistically significant blood cellular or biochemical alterations associated with the administration of flunixin meglumine. There were no significant clinicopathological differences between healthy foals treated with the recommended dosage of flunixin meglumine and those treated with physiological saline.
在新生马驹中研究了每日静脉注射剂量为0.55、1.1、2.2和6.6毫克/千克的氟尼辛葡甲胺，持续五天的效果。使用六只两日龄马驹评估每种剂量的效果。每天对马驹进行检查，并在第1、3和6天采集血样。六天后对所有马驹实施安乐死，进行尸体剖检并检查病变。主要临床异常为腹泻，但发病率与所给予的氟尼辛葡甲胺剂量无关。接受6.6毫克/千克氟尼辛葡甲胺的马驹比接受生理盐水治疗的马驹有明显更多的胃肠道溃疡、更严重的盲肠病变和更高的盲肠瘀点评分。6.6毫克/千克治疗组的马驹在研究期间总蛋白损失更大，但差异不显著。与氟尼辛葡甲胺给药相关的血细胞或生化改变无统计学意义。接受推荐剂量氟尼辛葡甲胺治疗的健康马驹与接受生理盐水治疗的马驹之间无显著的临床病理差异。
