Collins L G, Tyler D E
J Am Vet Med Assoc. 1984 Mar 15;184(6):699-703.
In a retrospective study of 269 horses that had been treated with phenylbutazone, horses receiving less than or equal to 8.8 mg/kg of body weight/day for less than or equal to 4 days or 2 to 4 mg/kg of body weight/day for up to 50 days remained clinically normal. Anorexia, depression, colic, hypoproteinemia, diarrhea, melena, weight loss, ventral edema, petechial hemorrhages of mucous membranes, oral and gastrointestinal tract erosions and ulcers, renal papillary necrosis, and death were among the complications seen in horses that had received greater than 8.8 mg/kg of body weight/day. In 2 cases, signs suggestive of gastrointestinal-related shock were also evident.
在一项对269匹接受过保泰松治疗的马匹的回顾性研究中，体重每天每千克接受小于或等于8.8毫克、持续时间小于或等于4天的马匹，或体重每天每千克接受2至4毫克、持续时间长达50天的马匹，临床上仍保持正常。接受大于体重每天每千克8.8毫克的马匹出现的并发症包括厌食、抑郁、绞痛、低蛋白血症、腹泻、黑粪症、体重减轻、腹部水肿、黏膜瘀点性出血、口腔和胃肠道糜烂及溃疡、肾乳头坏死和死亡。在2例病例中，还明显出现了提示与胃肠道相关休克的体征。
