Salans L B, Horton E S, Sims E A
J Clin Invest. 1971 May;50(5):1005-11. doi: 10.1172/JCI106570.
Studies of adipose tissue cellularity were carried out in a group of nonobese adult male volunteers who gained 15-25% of their body weight as the result of prolonged high caloric intake. Adipose cell size (lipid content per cell) was determined in tissue obtained from three subcutaneous sites (gluteal, anterior abdominal wall, and triceps) and total adipose cell number estimated from measurement of total body fat. Five experimental subjects gained an average of 16.2 kg of body weight, of which 10.4 kg was determined to be fat. Expansion of the adipose mass was accompanied by a significant and relatively uniform increase in fat cell size in each subcutaneous site tested. Total adipose cell number did not change as a result of weight gain and expansion of the adipose depot in adult life. Subsequent loss of weight and restoration of original body fat was associated with a reduction in adipose cell size at each subcutaneous site, but no change in total number. In two control subjects who neither gained nor lost weight there were no changes in total adipose cell number or cell size. These observations suggest that expansion and retraction of the adipose depot in adult life is accompanied by changes in adipose cell size only. Significant differences in both the size and total number of adipose cells were observed between subjects in both the experimental and control groups. In addition, within individuals of both groups there were significant differences in cell size when adipose cells from the three subcutaneous sites were compared. These findings indicate that wide variations in adipose cell size and number exist in nonobese individuals having similar adipose depot sizes.
对一组非肥胖成年男性志愿者进行了脂肪组织细胞构成的研究，这些志愿者因长期高热量摄入体重增加了15% - 25%。在从三个皮下部位（臀、腹壁前部和肱三头肌）获取的组织中测定脂肪细胞大小（每个细胞的脂质含量），并通过测量全身脂肪来估算脂肪细胞总数。五名实验对象平均体重增加了16.2千克，其中10.4千克被确定为脂肪。脂肪量的增加伴随着每个测试皮下部位脂肪细胞大小显著且相对均匀的增加。在成年期，体重增加和脂肪储存库的扩大并没有导致脂肪细胞总数的变化。随后体重减轻并恢复到原来的体脂水平与每个皮下部位脂肪细胞大小的减小有关，但细胞总数没有变化。在两名体重既未增加也未减少的对照对象中，脂肪细胞总数和细胞大小均无变化。这些观察结果表明，成年期脂肪储存库的扩大和收缩仅伴随着脂肪细胞大小的变化。在实验组和对照组的受试者之间，脂肪细胞的大小和总数均存在显著差异。此外，在两组个体中，当比较来自三个皮下部位的脂肪细胞时，细胞大小也存在显著差异。这些发现表明，在具有相似脂肪储存库大小的非肥胖个体中，脂肪细胞大小和数量存在广泛差异。
