吸入硫酸气溶胶对小鼠和兔子的胚胎毒性。

Embryotoxicity of inhaled sulfuric acid aerosol in mice and rabbits.

作者信息

Murray F J, Schwetz B A, Nitschke K D, Crawford A A, Quast J F, Staples R E

出版信息

J Environ Sci Health C. 1979;13(3):251-66.

Abstract

The effect of inhaled sulfuric acid (H2SO4) on embryonal and fetal development was assessed in CF-1 mice and in New Zealand white rabbits. Both species were exposed for 7 hr/day to 0, 5, or 20 mg H2SO4/m3 during the period of major organogenesis (mice, days 6 through 15 of gestation; rabbits, days 6 through 18 of gestation). Little evidence of toxicity was seen in the fetuses of mice or rabbits exposed to H2SO4. Slight maternal toxicity was seen at 20 mg H2SO4/m3 in both species. Teratogenicity was not observed in either mice or rabbits exposed to H2SO4.

摘要

在CF-1小鼠和新西兰白兔中评估了吸入硫酸（H₂SO₄）对胚胎和胎儿发育的影响。在主要器官形成期（小鼠为妊娠第6至15天；兔子为妊娠第6至18天），两种动物均每天暴露于0、5或20毫克H₂SO₄/立方米的环境中7小时。在暴露于H₂SO₄的小鼠或兔子胎儿中几乎没有发现毒性迹象。在两种动物中，20毫克H₂SO₄/立方米时均出现了轻微的母体毒性。暴露于H₂SO₄的小鼠或兔子均未观察到致畸性。