吸入苯对小鼠和家兔的胚胎毒性。

Embryotoxicity of inhaled benzene in mice and rabbits.

作者信息

Murray F J, John J A, Rampy L W, Kuna R A, Schwetz B A

出版信息

Am Ind Hyg Assoc J. 1979 Nov;40(11):993-8. doi: 10.1080/15298667991430604.

Abstract

The effect of inhaled benzene on embryonal and fetal development was assessed in mice and rabbits. CF-1 mice and New Zealand white rabbits were exposed to 0 or 500 ppm of benzene for 7 hr per day from days 6 through 15 (mice) and 6 through 18 (rabbits) of gestation. Little evidence of maternal toxicity was seen in either species. Although some signs of embryonal toxicity were observed in both mice and rabbits, a teratogenic effect was not discerned in either species inhaling 500 ppm of benzene.

摘要

在小鼠和兔子身上评估了吸入苯对胚胎和胎儿发育的影响。CF-1小鼠和新西兰白兔在妊娠第6天至第15天（小鼠）和第6天至第18天（兔子）期间，每天暴露于0或500 ppm的苯中7小时。在这两个物种中均未观察到明显的母体毒性迹象。虽然在小鼠和兔子中均观察到了一些胚胎毒性迹象，但吸入500 ppm苯的两个物种均未发现致畸作用。