Orsulak P J, Schildkraut J J
Ther Drug Monit. 1979;1(2):199-208. doi: 10.1097/00007691-197901020-00002.
A brief review of the literature surrounding the relationship between plasma levels of tricyclic antidepressants currently available in the United States and clinical efficacy is presented. While therapeutic ranges for plasma levels of some tricyclic antidepressants are reasonably well established, the relationships between plasma levels of others and clinical efficacy require further clarification. Conditions under which plasma level measurements are clinically useful and factors that alter steady-state plasma levels are discussed.
本文简要回顾了美国目前可用的三环类抗抑郁药血浆水平与临床疗效之间关系的相关文献。虽然一些三环类抗抑郁药的血浆治疗范围已得到合理确定，但其他药物的血浆水平与临床疗效之间的关系仍需进一步阐明。文中讨论了血浆水平测量在临床上有用的条件以及改变稳态血浆水平的因素。
