Nies A, Robinson D S, Friedman M J, Green R, Cooper T B, Ravaris C L, Ives J O
Am J Psychiatry. 1977 Jul;134(7):790-3. doi: 10.1176/ajp.134.7.790.
Older depressed patients treated with imipramine or amitriptyline developed higher steady-state plasma levels of imipramine, desipramine, and amitriptyline. In imipramine-treated patients this finding was associated with a decreased rate of drug elimination from plasma. These findings provide at least a partial explanation for the increased susceptibility of the older patient to tricyclic antidepressant side effects and also provide a pharmacological rationale for use of lower dosages in this age group.
接受丙咪嗪或阿米替林治疗的老年抑郁症患者，其体内丙咪嗪、去甲丙咪嗪和阿米替林的稳态血浆水平较高。在接受丙咪嗪治疗的患者中，这一发现与药物从血浆中消除的速率降低有关。这些发现至少部分解释了老年患者对三环类抗抑郁药副作用易感性增加的原因，也为该年龄组使用较低剂量药物提供了药理学依据。
