一种使用氮敏感检测器测定血浆中阿米替林和去甲替林水平的改进气相色谱法。
An improved gas-liquid chromatographic procedure for the determination of amitriptyline and nortriptyline levels in plasma using nitrogen-sensitive detectors.
作者信息
Dhar A K, Kutt H
出版信息
Ther Drug Monit. 1979;1(2):209-16. doi: 10.1097/00007691-197901020-00003.
Abstract
An improved gas-liquid chromatographic procedure for the plasma level determination of amitriptyline and nortriptyline using nitrogen-sensitive detectors is described. Derivatization of the secondary amines using trifluoroacetic anhydride greatly improves the response and reproducibility of the assay. Plasma samples containing as little as 5 ng/ml of amitriptyline and nortriptyline can be assayed precisely and reproducibly, using protriptyline as internal reference standard.
摘要
本文描述了一种改进的气相色谱法，用于使用氮敏感检测器测定血浆中阿米替林和去甲替林的含量。使用三氟乙酸酐对仲胺进行衍生化可大大提高该测定方法的响应和重现性。以普罗替林作为内标，血浆中低至5 ng/ml的阿米替林和去甲替林样品均可进行精确且可重复的测定。
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