Rambeck B, Boenigk H E, Dunlop A, Mullen P W, Wadsworth J, Richens A
Ther Drug Monit. 1979;1(3):325-33. doi: 10.1097/00007691-197901030-00007.
The nomogram devised by Richens and Dunlop for predicting phenytoin dose has been tested in 127 residential epileptic patients, and the data obtained were used to prepare a revised version of the nomogram. In a further 78 patients, this new version was found to be superior to the original. The mean Km value was found to be 23.8 mumoles/liter. Km was independent of age and body surface area, but Dmax correlated positively with the latter two variables.
里琴斯和邓洛普设计的用于预测苯妥英剂量的列线图在127名住院癫痫患者中进行了测试，并将获得的数据用于编制列线图的修订版。在另外78名患者中，发现这个新版本优于原版。发现平均Km值为23.8微摩尔/升。Km与年龄和体表面积无关，但最大消除率（Dmax）与后两个变量呈正相关。
