Soldin S J, Hach E, Pollard A, Logan A G
Ther Drug Monit. 1979;1(3):399-408. doi: 10.1097/00007691-197901030-00013.
We report a high performance liquid chromatographic method for the analysis of hydrochlorothiazide in 500microliter of serum of 25 microliter of urine. The between-day precision of the analysis (CV 5.0-7.0%) is acceptable, as is the recovery of hydrochlorothiazide (90-96%) and trichloromethiazide (96%) added to serum. No drug or drug metabolite interferences have been noted. The method represents a considerable improvement over existing techniques described in the literature.
我们报告了一种高效液相色谱法，用于分析500微升血清或25微升尿液中的氢氯噻嗪。该分析的日间精密度（CV为5.0 - 7.0%）是可接受的，添加到血清中的氢氯噻嗪回收率（90 - 96%）和三氯噻嗪回收率（96%）也是如此。未发现药物或药物代谢物干扰。该方法相较于文献中描述的现有技术有显著改进。
