Thelle D S, Førde O H
Am J Epidemiol. 1979 Dec;110(6):708-15. doi: 10.1093/oxfordjournals.aje.a112851.
As a part of a survey for coronary risk factors, family history of myocardial infarction (MI) was obtained in 4806 men and women aged 20--49 years. The two groups of subjects with (510) and without (3533) first degree relatives with MI showed only minor differences with respect to serum cholesterol, blood pressure, blood glucose, serum triglycerides, relative body weight and cigarette consumption. As long as no other mechanism for transmission of familial risk is revealed, the occurrence of MI among first degree relatives therefore must be considered as independent and important coronary risk factor. The material was also analyzed with regard to the three ethnic groups--Lapps, Finns and Norsemen--which comprise the study population. A discrepancy between risk factor level and MI incidence between these three groups was observed.
作为一项冠心病危险因素调查的一部分,我们获取了4806名年龄在20至49岁之间的男性和女性的心肌梗死(MI)家族史。有一级亲属患MI的两组受试者(510人)和无一级亲属患MI的两组受试者(3533人)在血清胆固醇、血压、血糖、血清甘油三酯、相对体重和吸烟量方面仅存在微小差异。只要没有发现其他家族性风险的传播机制,因此一级亲属中MI的发生必须被视为独立且重要的冠心病危险因素。我们还对构成研究人群的三个种族群体——拉普人、芬兰人和挪威人——的资料进行了分析。观察到这三个群体之间危险因素水平与MI发病率存在差异。