Forde O H, Thelle D S
Am J Epidemiol. 1977 Mar;105(3):192-9. doi: 10.1093/oxfordjournals.aje.a112375.
In a population survey for risk factors associated with coronary heart disease among 6595 men aged 20-49 years of age, a family history of myocardial infarction (MI) was obtained by interview. A high degree of concurrence (78%) was found between the reported and confirmed diagnoses. Subjects who had evidence of a previous MI had a significantly higher frequency of first degree relatives with MI compared to healthy men of the same age. In subjects with first degree relatives of either sex suffering from MI before age 50, the mean serum cholesterol concentration was found to be slightly but not significantly elevated. However, when the relatives were females below age 50, the subjects had significantly elevated mean systolic blood pressure (0.05 greater than p greater than 0.01). The differences between subjects with a positive and negative family history of MI were surprisingly small. Correspondingly, there was no difference in the frequency of MI relatives in subjects belonging to the upper and lower quintiles of the serum cholesterol and blood pressure distribution. The slight elevations in serum cholesterol and blood pressure contribute only to a very small extent to the increased risk to subjects with a positive family history.
在一项针对6595名年龄在20至49岁男性的冠心病相关危险因素的人群调查中，通过访谈获取了心肌梗死（MI）家族史。报告诊断与确诊诊断之间存在高度一致性（78%）。与同龄健康男性相比，有既往心肌梗死证据的受试者一级亲属患心肌梗死的频率显著更高。在一级亲属（无论男女）在50岁之前患心肌梗死的受试者中，发现其平均血清胆固醇浓度略有升高，但无统计学意义。然而，当亲属为50岁以下女性时，这些受试者的平均收缩压显著升高（0.05＞p＞0.01）。有心肌梗死家族史阳性和阴性的受试者之间的差异小得出奇。相应地，在血清胆固醇和血压分布处于上五分位数和下五分位数的受试者中，心肌梗死亲属的频率没有差异。血清胆固醇和血压的轻微升高对有阳性家族史的受试者增加的风险贡献极小。
