Zardi O, Soubotian B
Biochem Exp Biol. 1979;15(3):223-8.
Starting from the epidemiological investigation on a sample of 22.560 subjects of different chronological age classes in the Latium region with the research of hemoagglutinoinhibiting antibodies of the Rubella virus, and of 9.800 subjects with the research of hemoagglutinoinhibiting antibodies of the Measles virus, the authors observe that the diffusion of the seroprotection presents on an average 82.5% for Rubella and 79.8% for Measles. On the strength of the results, referred also according to the established chronological age classes, any obligatory treatment against Rubella is excluded in prepuberal age. In order to prevent the risk of congenital malformation in cases of pregnant and not seroprotected subjects who, during the first three months of gestation might come into contact with sick affected by Rosolia or with healthy carriers, the authors suggest the vaccination three months before the conception. Evidently, this involves a screening of the adult female population before their marriage. On the contrary as concerns Measles, the vaccination within the second year of life is being hypothesized exactly on the basis of the consideration that this is a matter of a serious illness and not always free from grave complications. In these cases, after shortly referring on the results of the experiments of different authors, the mixed anti-Measles and anti-Rubella vaccination might be taken into consideration, though with all the precautions that are suggested.
作者对拉齐奥地区22560名不同年龄阶段的受试者进行了风疹病毒血凝抑制抗体研究的流行病学调查，并对9800名受试者进行了麻疹病毒血凝抑制抗体研究。作者观察到，风疹的血清保护率平均为82.5%，麻疹为79.8%。根据这些结果，结合已确定的年龄阶段，排除了青春期前对风疹进行任何强制性治疗的可能性。为了防止未获得血清保护的孕妇在妊娠前三个月接触到玫瑰疹患者或健康携带者而导致先天性畸形的风险，作者建议在受孕前三个月进行疫苗接种。显然，这需要在成年女性婚前进行筛查。相反，对于麻疹，基于这是一种严重疾病且并非总是没有严重并发症的考虑，假设在生命的第二年进行疫苗接种。在这些情况下，在简要提及不同作者的实验结果后，可以考虑联合麻疹和风疹疫苗接种，但要采取所有建议的预防措施。
