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骨髓瓶培养——一种用于检查早期红细胞生成分化事件的系统。

Marrow flask cultures -- a system for examining early erythropoietic differentiation events.

作者信息

Eaves C J, Humphries R K, Eaves A C

出版信息

Blood Cells. 1979 Aug;5(3):377-87.

PMID:555694
Abstract

A technique for observing in flask cultures the differentiation and proliferation of murine CFU-S into each of the three myeloid lines is described. The differentiation of cells along the erythroid pathway is arrested at a very early stage making it possible to obtain large numbers of primitive erythropoietic cells derived from adult murine bone marrow. The pattern of differentiation obtained from these BFU-E suggests that the capacity for granulopoiesis is usually lost before a committment to either megakaryopoiesis or erythropoiesis is made.

摘要

本文描述了一种在培养瓶培养物中观察小鼠CFU-S向三种髓系细胞系分化和增殖的技术。细胞沿红系途径的分化在很早阶段就被阻断，从而有可能获得大量源自成年小鼠骨髓的原始造血红细胞。从这些BFU-E获得的分化模式表明，粒细胞生成能力通常在向巨核细胞生成或红细胞生成定向分化之前就已丧失。

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Blood Cells. 1979 Aug;5(3):377-87.
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