Jacrot M, Mouriquand J, Mouriquand C, Saez S
Cancer Lett. 1979 Dec;8(2):147-53. doi: 10.1016/0304-3835(79)90008-9.
166 Sprague-Dawley Rats (148 males and 118 females) submitted to different hormonal conditions were exposed to 3 repeated whole-body irradiations of 14.8 MeV neutrons or sham-irradiated between 50 and 65 days of age (total absorbed doses: 3 x 2 rad and 3 x 8 rad). They were observed for 11 months. In the male group, a small number of tumors was obtained. In the female group, 75 breast neoplasms were scored in 41 of 78 irradiated animals (54 fibroadenomas, 20 adenocarcinomas and 1 fibrosarcoma). A second group of benign and malignant tumors was observed from 200 days on. The neoplastic response to fast neutron fractionated irradiations was increased by pregnancy with subsequent lactation. Estradiol and progesterone receptors were measured in 34 tumor samples. Fibroadenomas (1;5) and adenocarcinomas (1;3) bound labelled steroids. Like in human breast cancer metastases, steroid receptors are found in recurrences only if present in the primary tumor.
166只Sprague-Dawley大鼠（148只雄性和118只雌性）在不同激素条件下，于50至65日龄期间接受3次14.8兆电子伏特中子的全身重复照射或假照射（总吸收剂量：3×2拉德和3×8拉德）。对它们进行了11个月的观察。在雄性组中，获得了少量肿瘤。在雌性组中，78只受照射动物中的41只出现了75个乳腺肿瘤（54个纤维腺瘤、20个腺癌和1个纤维肉瘤）。从200天起观察到第二组良性和恶性肿瘤。妊娠并随后哺乳会增加对快中子分次照射的肿瘤反应。在34个肿瘤样本中测量了雌二醇和孕酮受体。纤维腺瘤（1；5）和腺癌（1；3）结合标记类固醇。如同在人类乳腺癌转移中一样，只有在原发性肿瘤中存在类固醇受体时，才会在复发中发现它们。
