Konishi Y, Kondo H, Inui S, Denda A, Ikeda T, Kojima K
Gan. 1978 Feb;69(1):77-84.
The organotropic effect of N-bis(2-hydroxypropyl)nitrosamine (DHPN) orally administered to mice was studied. The main targets for the carcinogenic effect of DHPN were the lung and liver, with tumors induced by doses greater than 100 ppm DHPN for 16 weeks. The highest incidence was seen in liver vascular tumors including hemangioma, hemangioendothelioma, and hemangioendothelial sarcoma in mice treated with 1,000 ppm DHPN. Lung tumors were alveolar adenoma and adenocarcinoma. No pancreatic tumors were found. The present results suggest that the carcinogenic response in mice to DHPN was similar to that in rats and guinea pigs but different from that in hamsters.
研究了口服给予小鼠N-双（2-羟丙基）亚硝胺（DHPN）的器官亲和性效应。DHPN致癌作用的主要靶器官是肺和肝，剂量大于100 ppm的DHPN持续给药16周可诱发肿瘤。在用1000 ppm DHPN处理的小鼠中，肝血管肿瘤（包括血管瘤、血管内皮瘤和血管内皮肉瘤）的发生率最高。肺肿瘤为肺泡腺瘤和腺癌。未发现胰腺肿瘤。目前的结果表明，小鼠对DHPN的致癌反应与大鼠和豚鼠相似，但与仓鼠不同。
