Yamamoto H
J Toxicol Sci. 1985 Nov;10(4):315-21. doi: 10.2131/jts.10.315.
The tumorigenesis and cystic lesion by a single intraperitoneal administration (ip) of N-bis (2-hydroxypropyl)nitrosamine (DHPN) for 52 weeks were studied in ddY mice. The amount of DHPN was 1000 mg/kg in group I, 500 mg/kg in group II, 250 mg/kg in group III, 125 mg/kg in group IV and 0 mg/kg in group V. The tumorigenesis of DHPN was found in the lung and liver. However, cystic lesion was observed only in the liver. Lung tumors were adenoma, adenocarcinoma and squamous cell carcinoma. As liver tumors, adenoma, hepatocellular carcinoma, cholangioma and hemangioma were observed only in the mice treated with DHPN. Incidence of cystic lesion in the liver was detected in all groups treated with DHPN. Histologically, cystic lesion of the liver showed four patterns of bile duct-like, sinusoid-like, hepatocyte-like and mixed.
在ddY小鼠中研究了单次腹腔注射（ip）N-双（2-羟丙基）亚硝胺（DHPN）52周后的肿瘤发生和囊性病变情况。I组中DHPN的剂量为1000mg/kg，II组为500mg/kg，III组为250mg/kg，IV组为125mg/kg，V组为0mg/kg。在肺和肝脏中发现了DHPN的肿瘤发生情况。然而，仅在肝脏中观察到囊性病变。肺肿瘤为腺瘤、腺癌和鳞状细胞癌。作为肝脏肿瘤，仅在接受DHPN治疗的小鼠中观察到腺瘤、肝细胞癌、胆管瘤和血管瘤。在用DHPN治疗的所有组中均检测到肝脏囊性病变的发生率。组织学上，肝脏的囊性病变表现为胆管样、窦状隙样、肝细胞样和混合型四种模式。
