Bacharach S L, Green M V, Borer J S, Douglas M A, Ostrow H G, Johnston G S
J Nucl Med. 1977 Jan;18(1):79-84.
A minicomputer-based system is described that allows real-time construction and simultaneous display, in flicker-free movie format, of a cardiac-cycle-spanning sequence of ECG-gated scintigraphic images. In as little as 2 min, the endless-loop flicker-free movier clearly displays cardiac anatomy, time-dependent volume variations of cardiac chambers, and abnormalities of cardiac wall motion that would be difficult or impossible to detect from static gated images. Simultaneously, a time-activity curve with high temporal resolution can be generated from a previously defined region of interest, thereby quantifying additional parameters of cardiac function. Because the movie and time-activity curve are displayed in real time and require only a short data-collection interval to achieve statistical reliability, the physician can use the system interactively, modifying the form, intensity, or duration of diagnostic and therapeutic interventions based on the observed response. This system is well suited for intervention studies, for continuous cardiac monitoring, and for the rapid screening of patients with suspected cardiac disease.
本文描述了一种基于小型计算机的系统，该系统能够以无闪烁电影格式实时构建并同时显示跨越心动周期的心电图门控闪烁扫描图像序列。只需短短2分钟，无闪烁循环电影就能清晰展示心脏解剖结构、心腔随时间变化的容积以及心脏壁运动异常，而这些从静态门控图像中很难或无法检测到。同时，可以从预先定义的感兴趣区域生成具有高时间分辨率的时间-活性曲线，从而量化心功能的其他参数。由于电影和时间-活性曲线实时显示，且仅需较短的数据采集间隔就能达到统计可靠性，医生可以交互式地使用该系统，根据观察到的反应修改诊断和治疗干预的形式、强度或持续时间。该系统非常适合干预研究、连续心脏监测以及对疑似心脏病患者的快速筛查。
