Guillebaud J, Bonnar J, Morehead J, Matthews A
Lancet. 1976 Feb 21;1(7956):387-90. doi: 10.1016/s0140-6736(76)90216-6.
The effect of three intrauterine contraceptive devices (I.U.D.)-Lippes D, Dalkon Shield, and Copper 7-on menstrual blood-loss has been studied serially by objective methods in 279 women. All the women had a minimum of two cycles following delivery, abortion, cessation of lactation, or previous pill or I.U.D. use. All pads and tampons used for two further menstrual cycles before and for 12 cycles after I.U.D. insertion were collected, and the blood-loss was measured by extracting the haemoglobin by conversion to alkaline haematin. Mean menstrual blood-loss increased with all three devices. The amount of loss, the percentage of women losing more than 80 ml, the decline in haemoglobin concentration, and the incidence of anaemia during the 12 cycles following insertion were all greater among users of the Lippes Loop than of the Copper 7 with generally intermediate values for Dalkon Shield users. The mean increases in blood-loss were: for parous women fitted with the Lippes Loop, 48 ml, with the Dalkon Shield, 34 ml, and with the Copper 7, 18 ml; for nulliparae fitted with the small size of Dalkon Shield, 27 ml, and, with the Copper 7, 19 ml.
采用客观方法对279名妇女连续研究了三种宫内节育器(IUD)——利普斯D型、达康盾和铜7型——对月经失血的影响。所有妇女在分娩、流产、停止哺乳或先前使用避孕药或宫内节育器后至少经历两个月经周期。收集了在宫内节育器插入前两个月经周期以及插入后12个月经周期使用的所有卫生巾和卫生棉条,并通过将血红蛋白转化为碱性高铁血红蛋白来提取血红蛋白,从而测量失血量。使用所有三种宫内节育器后,平均月经失血量均增加。在插入后的12个月经周期中,利普斯环使用者的失血量、失血超过80毫升的女性百分比、血红蛋白浓度下降以及贫血发生率均高于铜7型使用者,达康盾使用者的各项指标通常介于两者之间。失血量的平均增加量分别为:佩戴利普斯环的经产妇增加48毫升,佩戴达康盾的增加34毫升,佩戴铜7型的增加18毫升;佩戴小号达康盾的未产妇增加27毫升,佩戴铜7型的增加19毫升。