Grimes D S
Lancet. 1976 Feb 21;1(7956):395-7. doi: 10.1016/s0140-6736(76)90219-1.
A diet high in refined carbohydrate is implicated in the aetiology of some diseases of the colon-i.e., diverticular disease, irritable bowel syndrome, ulcerative colitis, non-occlusive ischaemic colitis, and pseudomembranous colitis. It is suggested that spasm of the smooth muscle is the common pathogenetic mechanism in these colonic diseases. The strength of the spasm producing increased pressure in the colonic lumen or wall and the length of time for which the colon has been affected are believed to determine the type of disease resulting. A diet high in refined carbohydrate allows the intense muscle spasm to occur because the physical buffering effect of faecal bulk is considerably reduced.
高精制碳水化合物饮食与某些结肠疾病的病因有关，即憩室病、肠易激综合征、溃疡性结肠炎、非闭塞性缺血性结肠炎和假膜性结肠炎。有人认为平滑肌痉挛是这些结肠疾病常见的发病机制。产生结肠腔内或肠壁压力增加的痉挛强度以及结肠受影响的时间长度被认为决定了所导致疾病的类型。高精制碳水化合物饮食会导致强烈的肌肉痉挛，因为粪便体积的物理缓冲作用会大大降低。
