Lorez H P, Da Prada M, Rendu F, Pletscher A
J Lab Clin Med. 1977 Jan;89(1):200-6.
In the blood platelets of various species exposed to mepacrine, the average number of green-yellow fluorescent granules (probably identical with the 5-hydroxytryptamine [5-HT] storage organelles) corresponded to that of flashes emitted by the platelets on prolonged irradiation with violet-blue light. In platelets of fawn-hooded rats the number of granules did not markedly differ from that of normal rat platelets, but the fluorescence intensity and the uptake of mepacrine in vitro showed a marked decrease and the flashes were less numerous. The heavy population of human platelets exhibited considerably more granular structures than the light population. The data suggest that (1) in normal, mepacrine-loaded platelets one flash corresponds to one 5-HT organelle and (2) mepacrine is a useful tool for investigating the number and function of the 5-HT organelles in live platelets and possibly for studying platelet age.
在接触了阿的平的各种物种的血小板中，绿黄色荧光颗粒（可能与5-羟色胺[5-HT]储存细胞器相同）的平均数量与血小板在长时间紫光蓝光照射下发出的闪光数量相对应。在淡褐色大鼠的血小板中，颗粒数量与正常大鼠血小板的颗粒数量没有明显差异，但荧光强度和阿的平的体外摄取量显著降低，且闪光数量较少。高密度人群的血小板比低密度人群的血小板表现出更多的颗粒结构。这些数据表明：（1）在正常的、加载了阿的平的血小板中，一次闪光对应一个5-HT细胞器；（2）阿的平是研究活血小板中5-HT细胞器数量和功能以及可能用于研究血小板年龄的有用工具。
