一些β-内酰胺抗生素在水溶液中形成的聚合材料的量和抗原性的比较。
A comparison of the amounts and the antigenicity of polymeric materials formed in aqueous solution by some beta-lactam antibiotics.
作者信息
Smith H, Dewdney J M, Wheeler A W
出版信息
Immunology. 1971 Sep;21(3):527-33.
Abstract
Concentrated aqueous solutions of some β-lactam antibiotics were stored for 14 days. Samples were then subjected to gel filtration and fractions in the high molecular weight regions of the eluate were collected and lyophilized. The yields of materials from solutions of various β-lactam antibiotics were compared and the antigenicity of the materials was assessed by their ability to react with antibodies of benzylpenicilloyl specificity raised in rabbits and tested in guinea-pigs by passive cutaneous anaphylaxis.
摘要
将一些β-内酰胺抗生素的浓水溶液储存14天。然后对样品进行凝胶过滤，收集洗脱液中高分子量区域的级分并冻干。比较了各种β-内酰胺抗生素溶液中物质的产率，并通过它们与在兔体内产生的苄青霉素特异性抗体反应的能力来评估这些物质的抗原性，该抗体通过豚鼠被动皮肤过敏反应进行测试。
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本文引用的文献
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STUDIES IN HUMAN PENICILLIN ALLERGY: A COMPARISON OF VARIOUS PENICILLOYL-POLYLYSINES.
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N(ALPHA-D-PENICILLOYL) AMINES AS UNIVALENT HAPTEN INHIBITORS OF ANTIBODYDEPENDENT ALLERGIC REACTIONS TO PENICILLIN.N（α-D-青霉烯酰）胺作为单价半抗原抑制剂用于抑制青霉素的抗体依赖性过敏反应。
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Purification of antibodies with immunoadsorbents prepared using bromoacetyl cellulose.使用溴乙酰纤维素制备的免疫吸附剂纯化抗体。
Immunochemistry. 1967 Jan;4(1):11-22. doi: 10.1016/0019-2791(67)90192-9.
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Laboratory and pharmacological studies in man with hetacillin and ampicillin.在人体中使用缩酮氨苄青霉素和氨苄青霉素的实验室及药理学研究。
Br Med J. 1967 Jun 24;2(5555):804-8. doi: 10.1136/bmj.2.5555.804.
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A penicilloylated protein impurity as a source of allergy to benzylpenicillin and 6-aminopenicillanic acid.一种青霉酰化蛋白杂质，作为对苄青霉素和6-氨基青霉烷酸过敏的来源。
Lancet. 1967 Jun 3;1(7501):1175-7. doi: 10.1016/s0140-6736(67)92838-3.
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