Culebras A, Podolsky S, Leopold N A
Neurology. 1977 Feb;27(2):165-7. doi: 10.1212/wnl.27.2.165.
There is evidence that in myotonic dystrophy, the endocrine and central nervous systems are affected. To study a possible relationship between both defects, we investigated nocturnal sleep patterns and associated growth hormone secretion in two men and three women with myotonic dystrophy. In three patients who were clinically the most severely affected by myotonic dystrophy, plasma growth hormone elevations related to the slow-wave phase of sleep were absent. The two least severely affected patients had plasma growth hormone increases of low magnitude and brief duration (from 0.4 ng per milliliter to 13.0 ng per milliliter). These data suggest a failure of integration at a subcortical level of the slow-wave phase of sleep with the hypothalamic-pituitary mechanisms of growth hormone secretion. Thalamic neuronal lesions occurring in myotonic dystrophy could be responsible for such failure.
有证据表明，强直性肌营养不良会影响内分泌和中枢神经系统。为了研究这两种缺陷之间可能存在的关系，我们调查了两名男性和三名女性强直性肌营养不良患者的夜间睡眠模式及相关生长激素分泌情况。在三名临床上受强直性肌营养不良影响最严重的患者中，与睡眠慢波期相关的血浆生长激素升高情况不存在。另外两名受影响最轻的患者血浆生长激素有小幅度升高且持续时间短暂（从每毫升0.4纳克升至13.0纳克）。这些数据表明，睡眠慢波期在皮层下水平与生长激素分泌的下丘脑 - 垂体机制之间的整合出现了障碍。强直性肌营养不良中发生的丘脑神经元损伤可能是导致这种障碍的原因。
