细菌感染患者的多形核白细胞趋化性
Polymorphonuclear leucocyte chemotaxis in patients with bacterial infections.
作者信息
Mowat A G, Baum J
出版信息
Br Med J. 1971 Sep 11;3(5775):617-9. doi: 10.1136/bmj.3.5775.617.
A new in vitro method of measuring the chemotaxis of polymorphonuclear leucocytes from peripheral blood has been used to calculate a chemotactic index. The mean chemotactic index in 15 patients with bacterial infection (434) was significantly less (P <0.0005) than in 15 normal controls (553) matched for age and sex. The reduction in chemotaxis could be correlated with the duration of the infection, with the greatest impairment being found in those patients with the shortest duration of infection. In five patients studied before and after appropriate therapy the chemotactic index returned to normal values with clearing of the infection. It is suggested that the impairment in chemotaxis may be due to prior phagocytosis of antibody-antigen complexes by the polymorphonuclear leucocytes.
一种测量外周血中多形核白细胞趋化性的新体外方法已被用于计算趋化指数。15例细菌感染患者（趋化指数为434）的平均趋化指数显著低于（P<0.0005）15名年龄和性别匹配的正常对照者（趋化指数为553）。趋化性的降低与感染持续时间相关，感染持续时间最短的患者趋化性受损最大。在5例接受适当治疗前后进行研究的患者中，随着感染的清除，趋化指数恢复到正常水平。有人提出，趋化性受损可能是由于多形核白细胞事先吞噬了抗体-抗原复合物。
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