Davidson G P, Townley R R
J Pediatr. 1977 Apr;90(4):590-4. doi: 10.1016/s0022-3476(77)80372-7.
Structural abnormalities and disaccharidase deficiency were demonstrated in biopsies of duodenal mucosa from four infants who had symptoms of failure to thrive and chronic diarrhea associated with a megaloblastic anemia. Goat's milk was the main dietary constituent for each infant for six to eight months prior to presentation. The structural abnormalities consisted of villous blunting, crypt hypertrophy, megaloblastic changes in epithelial cells, and nuclear enlargement. All changes reverted to normal with the addition of folic acid to the diet. This study provides evidence that nutritional folic acid deficiency can cause structural and functional alterations of the small intestine in infants.
在四名患有发育不良和慢性腹泻症状且伴有巨幼细胞贫血的婴儿的十二指肠黏膜活检中，发现了结构异常和双糖酶缺乏。在出现症状前的六至八个月里，山羊奶是每个婴儿的主要饮食成分。结构异常包括绒毛变钝、隐窝肥大、上皮细胞巨幼细胞改变和细胞核增大。饮食中添加叶酸后，所有变化均恢复正常。这项研究提供了证据，表明营养性叶酸缺乏可导致婴儿小肠的结构和功能改变。
