Campbell B A, Randall P J
Science. 1977 Mar 4;195(4281):888-91. doi: 10.1126/science.557236.
In adult rats amphetamine acts as a strong behavioral stimulant leading to a marked increase in random, nondirected locomotor activity. In contrast we report that amphetamine administered to preweanling rats in the presence of an anesthetized adult rat produces no visible increase in motor activity. Instead, it appears to enhance the normal tendency of neonatal rats to approach and maintain contact with conspecifics. In postweanling rats amphetamine disrupts the tendency to aggregate and produces an increase in behavioral activity comparable to that seen in adult rats. These findings may constitute the basis for an animal model of minimal brain dysfunction hyperkinesis.
在成年大鼠中，苯丙胺作为一种强效行为兴奋剂，会导致随机、无定向的运动活动显著增加。相比之下，我们报告称，在有麻醉的成年大鼠存在的情况下，给断奶前的大鼠施用苯丙胺，并未使运动活动出现明显增加。相反，它似乎增强了新生大鼠接近并与同种个体保持接触的正常倾向。在断奶后的大鼠中，苯丙胺会破坏聚集的倾向，并使行为活动增加，这与成年大鼠中观察到的情况相当。这些发现可能构成轻微脑功能障碍多动症动物模型的基础。
