Porrino L J, Rapoport J L, Behar D, Ismond D R, Bunney W E
Arch Gen Psychiatry. 1983 Jun;40(6):688-93. doi: 10.1001/archpsyc.1983.04390010098013.
Twenty-four-hour motor activity was assessed in a naturalistic setting in 12 hyperactive boys for four weeks (672 consecutive hours). Dextroamphetamine, 15 mg/day, or placebo was administered on alternate weeks, using a double-blind ABAB design. When the boys received dextroamphetamine, motor activity was significantly decreased for about eight hours after drug administration. This decrease was followed by a period of slight but significant increases in activity ("rebound"). Dextroamphetamine decreased activity most strikingly during structured classroom activity; during physical education, however, there was a significant drug-induced increase in motor activity.
在自然环境中对12名多动男孩的24小时运动活动进行了为期四周（连续672小时）的评估。采用双盲ABAB设计，每隔一周给予15毫克/天的右旋苯丙胺或安慰剂。当男孩们服用右旋苯丙胺时，给药后约8小时运动活动显著减少。这种减少之后是一段时间的活动轻微但显著增加（“反弹”）。右旋苯丙胺在结构化课堂活动期间最显著地降低了活动量；然而，在体育课期间，药物导致运动活动显著增加。
