Thieme R E, Dijkstra H, Stoof J C
Psychopharmacology (Berl). 1980 Feb;67(2):165-9. doi: 10.1007/BF00431972.
Three main symptoms of minimal brain dysfunction (MBD), a common disorder in children, are hyperactivity, learning disabilities, and attention deficits. Drugs like amphetamine and methylphenidate have been demonstrated to produce a significant behavioral improvement in these children. The behavioral response of young rats (3--4 weeks), with selective lesioning of the central dopaminergic system, to a novel environment was analyzed. Both the frequencies and durations of eight mutually exclusive and complementary behavioral categories were scored. By analyzing the behavior in this way it appeared that considerable hyperactivity and learning disabilities could be demonstrated in these rats. Moreover, the bout length of some behavioral categories was somewhat shortened, which might be an indication of deficits in attention. However, treatment of the animals with amphetamine did not produce any "therapeutic" effect on the three symptoms. Since pharmacotherapeutic support is, in our opinion, a "conditio sine qua non" for the validity of the model, we do not believe that the young DA-lesioned rat is an appropriate animal model for MBD.
轻微脑功能障碍（MBD）是儿童常见的一种病症，其主要有三大症状：多动、学习障碍和注意力缺陷。已证实，苯丙胺和哌醋甲酯等药物能使这些儿童的行为有显著改善。对选择性损伤中枢多巴胺能系统的幼鼠（3 - 4周龄）在新环境中的行为反应进行了分析。对八个相互排斥且互补的行为类别出现的频率和持续时间进行了评分。通过这种方式分析行为发现，这些大鼠表现出相当程度的多动和学习障碍。此外，某些行为类别的发作时长有所缩短，这可能表明存在注意力缺陷。然而，用苯丙胺治疗这些动物并未对这三种症状产生任何“治疗”效果。由于我们认为药物治疗支持是该模型有效性的“必要条件”，所以我们不认为幼龄多巴胺能损伤大鼠是MBD的合适动物模型。
