人类皮肤炎症中前列腺素的恢复情况。
Recovery of prostaglandins in human cutaneous inflammation.
作者信息
Greaves M W, Sondergaard J, McDonald-Gibson W
出版信息
Br Med J. 1971 May 1;2(5756):258-60. doi: 10.1136/bmj.2.5756.258.
Abstract
An in-vivo skin perfusion technique has been used to study the pharmacological activity in inflamed skin of patients with allergic contact eczema. Perfusates from 35 out of 45 patients contained a smooth-muscle-contracting agent with prostaglandin-like properties. Solvent partition followed by thinlayer chromatography revealed this activity to be due to a mixture of prostaglandins E and F. This direct evidence supports the view that prostaglandins mediate inflammation in man.
摘要
一种体内皮肤灌注技术已被用于研究过敏性接触性皮炎患者炎症皮肤中的药理活性。45名患者中有35名的灌注液含有一种具有前列腺素样特性的平滑肌收缩剂。通过溶剂分配和薄层色谱分析表明，这种活性是由前列腺素E和F的混合物引起的。这一直接证据支持了前列腺素介导人类炎症的观点。
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