人皮肤中前列腺素的生物合成及其受皮质类固醇的抑制作用。
Prostaglandin biosynthesis by human skin and its inhibition by corticosteroids.
作者信息
Greaves M W, McDonald-Gibson W
出版信息
Br J Pharmacol. 1972 Sep;46(1):172-5. doi: 10.1111/j.1476-5381.1972.tb06861.x.
Abstract
Homogenates of human breast skin form prostaglandins E(2) and F(2alpha) in the presence of arachidonic acid substrate. Significant inhibition of biosynthesis of prostaglandin E(2) and F(2alpha) was observed in the presence of the anti-inflammatory corticosteroid fluocinolone acetonide. This effect was dose-related. By contrast no significant inhibition was observed in the presence of an approximately equimolar concentration of hydrocortisone.Since prostaglandins have been recovered from several types of inflammatory reactions and are capable of mediating most of the components of inflammation the possibility arises that corticosteroids may owe their anti-inflammatory activity at least in part to inhibition of prostaglandin biosynthesis.
摘要
在花生四烯酸底物存在的情况下，人乳房皮肤匀浆会形成前列腺素E(2)和F(2α)。在抗炎皮质类固醇醋酸氟轻松存在时，观察到前列腺素E(2)和F(2α)生物合成受到显著抑制。这种作用与剂量相关。相比之下，在存在近似等摩尔浓度的氢化可的松时，未观察到显著抑制作用。由于已在多种炎症反应中检测到前列腺素，且它们能够介导炎症的大多数成分，因此有可能皮质类固醇的抗炎活性至少部分归因于对前列腺素生物合成的抑制。
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本文引用的文献
1
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Nature. 1963 Nov 30;200:892-3. doi: 10.1038/200892b0.
2
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Br Med J. 1971 May 1;2(5756):258-60. doi: 10.1136/bmj.2.5756.258.
3
Efflux of prostaglandins in lymph from scalded tissues.前列腺素从烫伤组织的淋巴液中流出。
Acta Physiol Scand. 1970 Dec;80(4):46A-47A. doi: 10.1111/j.1748-1716.1970.tb04869.x.
4
Pharmacologic agents released in ultraviolet inflammation studied by continuous skin pefusion.通过连续皮肤灌注研究紫外线炎症中释放的药理剂。
J Invest Dermatol. 1970 May;54(5):365-7. doi: 10.1111/1523-1747.ep12259058.
5
Mechanism of prostaglandin biosynthesis. 18 O2 studies on PGF 1 alpha.前列腺素生物合成机制。关于前列腺素F1α的18O2研究。
Ann N Y Acad Sci. 1971 Apr 30;180:126-37. doi: 10.1111/j.1749-6632.1971.tb53192.x.
6
Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.抑制前列腺素合成作为阿司匹林类药物的作用机制。
Nat New Biol. 1971 Jun 23;231(25):232-5. doi: 10.1038/newbio231232a0.
7
Fever produced by prostaglandin E1.前列腺素E1产生的发热。
J Physiol. 1971 Sep;217(3):547-56. doi: 10.1113/jphysiol.1971.sp009585.
8
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9
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