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苯酚暴露评估:苯酚蒸气在肺部的吸收、经皮肤的吸收以及苯酚在尿液中的排泄。

Evaluation of exposure to phenol: absorption of phenol vapour in the lungs and through the skin and excretion of phenol in urine.

作者信息

Piotrowski J K

出版信息

Br J Ind Med. 1971 Apr;28(2):172-8. doi: 10.1136/oem.28.2.172.

DOI:10.1136/oem.28.2.172
PMID:5572685
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1009262/
Abstract

172-178. Volunteers were exposed to phenol vapour (5 to 25 mg/m) by inhalation and through the skin, respectively, and the excretion of phenol in urine was examined. The retention of vapour in the lungs decreased from about 80 to 70% in the course of exposure. The absorption of vapour through the whole of the skin was approximately proportional to the concentration of vapour used, the absorption rate being somewhat lower than in the lungs. Almost 100% of the phenol was excreted in the urine within one day. The rate of excretion of phenol in the urine may be used as an exposure test which permits the absorbed dose to be estimated with a precision of about ±2 mg.

摘要

172 - 178. 志愿者分别通过吸入和皮肤接触苯酚蒸气(5至25毫克/立方米),并检测尿中苯酚的排泄情况。在接触过程中,肺部蒸气潴留率从约80%降至70%。经整个皮肤吸收的蒸气量大致与所用蒸气浓度成正比,吸收速率略低于肺部。几乎100%的苯酚在一天内随尿液排出。尿中苯酚的排泄率可用作暴露试验,据此可精确估计吸收剂量,精度约为±2毫克。

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本文引用的文献

1
Studies in detoxication. 19. The metabolism of benzene. I. (a) The determination of phenol in urine with 2:6-dichloroquinonechloroimide. (b) The excretion of phenol, glucuronic acid and ethereal sulphate by rabbits receiving benzene and phenol. (c) Observations on the determination of catechol, quinol and muconic acid in urine.解毒作用的研究。19. 苯的代谢。I. (a) 用2:6 - 二氯醌氯亚胺测定尿中的苯酚。(b) 接受苯和苯酚的兔子对苯酚、葡萄糖醛酸和硫酸酯的排泄。(c) 关于尿中儿茶酚、对苯二酚和粘康酸测定的观察。
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[Relationship of the sulphate and phenol test in urine to benzene concentration in the air].
Prac Lek. 1955 Feb;7(1):1-7.
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The measurement of phenol in urine as an index of benzene exposure.
Am Ind Hyg Assoc J. 1961 Oct;22:362-7. doi: 10.1080/00028896109343422.
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[Diuresis and the phenol test].
Cesk Hyg. 1962 Feb;7:49-52.
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Blood phenol level after topical application of phenol-containing preparations.含酚制剂局部应用后的血酚水平。
J Am Med Assoc. 1953 Jun 6;152(6):506-9. doi: 10.1001/jama.1953.03690060022008.
6
Further investigations on the evaluation of exposure to nitrobenzene.关于硝基苯暴露评估的进一步研究。
Br J Ind Med. 1967 Jan;24(1):60-5. doi: 10.1136/oem.24.1.60.