Piotrowski J
Br J Ind Med. 1967 Jan;24(1):60-5. doi: 10.1136/oem.24.1.60.
Metabolic studies were performed on men exposed to nitrobenzene vapour under experimental conditions. Absorption was estimated by the analysis of urine for -nitrophenol. About half as much vapour was absorbed through the skin as through the lungs. In inhalation studies the accumulation of nitrobenzene in the course of repeated exposures was investigated. It was found that -nitrophenol was excreted in the urine in increasing amounts on successive days of exposure, reaching, by the end of a week, levels approximately two and a half times as high as on the first day. The specificity of the -nitrophenol test on urine was studied using rats. Of all nitro-compounds investigated only chloronitrobenzenes, especially the -isomer, gave interfering compounds in the urine. -Chloronitrobenzene gave lower results than nitrobenzene by a factor of 3.
在实验条件下，对接触硝基苯蒸气的男性进行了代谢研究。通过分析尿液中的对硝基苯酚来估算吸收量。经皮肤吸收的蒸气量约为经肺部吸收量的一半。在吸入研究中，对重复接触过程中硝基苯的蓄积情况进行了调查。结果发现，在连续接触的日子里，尿液中对硝基苯酚的排泄量不断增加，到一周结束时，其水平约为第一天的2.5倍。使用大鼠研究了尿液中对硝基苯酚检测的特异性。在所有研究的硝基化合物中，只有氯硝基苯，尤其是对位异构体，会在尿液中产生干扰化合物。对氯硝基苯的检测结果比硝基苯低3倍。
