接触萘的产业工人尿液中存在1-萘酚。
The presence of 1-naphthol in the urine of industrial workers exposed to naphthalene.
作者信息
Bieniek G
机构信息
Department of Biochemistry and Biophysics, Silesian Medical Academy, Sosnowiec, Poland.
出版信息
Occup Environ Med. 1994 May;51(5):357-9. doi: 10.1136/oem.51.5.357.
Abstract
1-Naphthol at concentrations ranging from 0.4 to 34.6 mg/l was found in urine collected directly after the end of the work shift from a group of industrial workers employed in distillation of naphthalene oil. The maximum excretion was found one hour after the end of the shift and the mean excretion rate was 0.57 mg/h. Coke plant workers exposed to naphthalene and other aromatic and polycyclic hydrocarbons also had 1-naphthol in their urine. Mean values were 0.89 mg/l (working with new technology) and 4.86 mg/l (working with old technology) and the excretion rates were 0.19 and 0.31 mg/h respectively. The maximum excretion was shifted to two to three hours after the end of the exposure. For non-exposed subjects the mean urinary 1-naphthol concentration was 120 micrograms/l and the excretion rate was 7.0 micrograms/h.
摘要
在一组从事萘油蒸馏工作的产业工人下班后直接采集的尿液中，发现1-萘酚浓度在0.4至34.6毫克/升之间。最大排泄量出现在轮班结束后1小时，平均排泄率为0.57毫克/小时。接触萘以及其他芳香烃和多环烃的炼焦厂工人尿液中也含有1-萘酚。平均值分别为0.89毫克/升（采用新技术工作）和4.86毫克/升（采用旧技术工作），排泄率分别为0.19毫克/小时和0.31毫克/小时。最大排泄量推迟到接触结束后两至三小时出现。对于未接触者，尿液中1-萘酚的平均浓度为120微克/升，排泄率为7.0微克/小时。
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本文引用的文献
1
The disposition of aromatic hydrocarbons in adult spot shrimp (Pandalus platyceros) and the formation of metabolites of naphthalene in adult and larval spot shrimp.
Xenobiotica. 1980 Mar;10(3):193-200. doi: 10.3109/00498258009033745.
2
Studies on the metabolism and excretion of 1-naphthol, 1-naphthyl-beta-D-glucuronide, and 1-naphthyl-beta-D-glucoside in the mouse.
Toxicol Appl Pharmacol. 1983 Mar 15;67(3):303-9. doi: 10.1016/0041-008x(83)90313-7.
3
In vivo quantification of renal glucuronide and sulfate conjugation of 1-naphthol and p-nitrophenol in the rat.
Biochem Pharmacol. 1984 Feb 1;33(3):419-27. doi: 10.1016/0006-2952(84)90235-1.
4
Reversed-phase high-performance liquid chromatography separation of human phenolic metabolites of propoxur (Baygon), carbofuran and carbaryl.
J Chromatogr. 1983 Mar 25;259(1):186-8. doi: 10.1016/s0021-9673(01)87995-4.
5
Evaluation of exposure to phenol: absorption of phenol vapour in the lungs and through the skin and excretion of phenol in urine.
Br J Ind Med. 1971 Apr;28(2):172-8. doi: 10.1136/oem.28.2.172.
6
Separation and determination of phenol, alpha-naphthol m- and p-, o-cresols and 2,5-xylenol, and catechol in the urine after mixed exposure to phenol, naphthalene, cresols, and xylenols.
Br J Ind Med. 1986 Aug;43(8):570-1. doi: 10.1136/oem.43.8.570.
7
Conjugative clearance of 1-naphthol and disposition of its glucuronide and sulfate conjugates in the isolated perfused rat kidney.
J Pharmacol Exp Ther. 1988 Jan;244(1):263-7.
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